Advances in Mechanisms and Treatment of Xenobiotic-Induced Cardiac Arrhythmias

Dear Colleagues,

Cardiovascular diseases represent a leading cause of morbidity and mortality in most countries. The origins of cardiovascular disease or disorder can be pathological, physiological, or pharmacological. The effect of xenobiotics such as pharmaceuticals on cardiovascular toxicity is not entirely understood. Many commonly used medications may induce or exacerbate arrhythmias detrimental to cardiovascular health. In addition, the potential overdoses caused by intentional or unintentional use could pose a severe threat to cardiovascular health. While the effects of pharmaceutical agents on QT prolongation are well known, conditions such as drug-induced bradyarrhythmias, atrial fibrillation/flutter, and Brugada syndrome are lesser known. Increasing evidence from epidemiological and mechanistic toxicology studies has shown that exposure to pollutants such as arsenic, lead, particulate matter, and pesticides can also contribute to cardiotoxicity. Despite the broad exposure to these xenobiotics, our current knowledge of the cardiotoxic effects mediated by these agents is poor. Research regarding the physiological and molecular mechanisms underlying arrhythmias, the correlation between pollutant exposure and cardiovascular risk, the relative susceptibility of a specific population to exposure, potential treatment and antidotes for reversing cardiotoxicity, etc. would collectively contribute towards our understanding of xenobiotic-induced cardiovascular disease.

We are pleased to invite you to contribute exciting topics that will help us understand xenobiotic-induced cardiotoxicity.  This Special Issue, “Advances in mechanisms and treatment of xenobiotic-induced cardiac arrhythmias”, aims to bring together relevant research submitted in the form of original research articles, reviews (narrative or systematic), short communications. The topics for the Special Issue may include (but are not limited to) the following: mechanisms underlying cardiac arrhythmias, mechanistic toxicology of drug-induced cardiac arrhythmias, toxicological studies pollutants that can precipitate arrhythmias, epidemiological studies relating exposure to cardiotoxicity, emerging treatments for reversing and treating cardiac arrhythmias, etc.

We look forward to receiving your contributions.

Dr. Diptiman Bose
Dr. Sun Shusen
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• xenobiotics
• pharmaceuticals
• cardiovascular disease
• cardiotoxicity
• cardiac arrhythmias