Special Issue "Bacterial Toxins – the Key Causal and Preventive Markers of Bacterial Disease"
Deadline for manuscript submissions: 31 December 2021.
Bacterial toxins are the one of the most crucial and potent tools that bacteria deploy in mechanistic infection and disease pathology. These key virulence markers can be involved in a variety of functions ranging from colonisation (by damaging cells and tissues), to enhanced pathogenesis (by disabling the innate and adaptive defences of host.) In special cases, these entities also help in faster transmission and spread of bacteria and disease.
Broadly, toxins can be classed into two types: exotoxin (acellular) and endotoxin (cellular). Exotoxins such as neurotoxins of Clostridium botulinum and Clostridium tetani, anthrax toxin of Bacillus anthracis, diarrheal toxin of Vibrio cholerae and ETEC, immunostimulatory superantigens (SAgs) of Staphylococcus aureus and Streptococcus pyogenes and choking toxins of Corynebacterium diphtheriae and Bordetella pertussis among many others, all modulate host cell function pathways. Endotoxins on the contrary are the lipopolysaccharides of bacterial cells and generally work as pyrogens. Due to their critical role in infection and disease, bacterial toxins make most convenient vaccine and therapeutic targets. Also, due to their immunomodulatory properties, modified versions of bacterial toxins are widely used as carrier proteins and adjuvants.
This Special Issue of Toxins will detail the history, evolution, and the mechanisms of action and host interaction of various bacterial toxins. In this issue, we will also showcase how these bacterial toxins have been exploited in advancement of scientific research, diagnostics, biochemistry-based high-throughput technologies and as components of life-saving drugs and vaccine formulations.
Dr. Ankur Mutreja
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- carrier protein