Special Issue "Spastic Muscle Features: Evaluation and Implications for Botulinum Toxin Treatment"
Deadline for manuscript submissions: 31 October 2021.
Interests: Topic: Neurological disorders
Special Issues and Collections in MDPI journals
Botulinum toxin (BoNT) has been proven to be effective and safe for the focal treatment of muscle spasticity. It acts in the cytosol of nerve endings and inhibits the release of acetylcholineat neuromuscular junctions by cleaving the synaptosomal-associated protein of 25 kDa, which is required for vesicle docking and, consequently, neurotransmitter release. The major causes of the loss of BoNT response in patients with focal spasticity are: inaccurate selection and identification of the correct muscle for injection, insufficient drug dosages, an inadequate injection technique, development of changes in the muscle, and formation of neutralizing antibodies. In particular, despite the fact that the features of spastic muscles (e.g., composition, neuromuscular activity, structure, rheological/mechanical properties, and metabolic state) may have some implications for BoNT treatment (e.g., drug response, dose definition, and injection targeting) they are not fully understood and considered in daily clinical practice, representing a sort of “black box” in some cases. The aim of this Special Issue is to present a collection of original research articles, reviews, and short communications on the evaluation of spastic muscle features from a BoNT administration perspective, with the aim of identifying their implications for the focal treatment of muscle spasticity.
Dr. Alessandro Picelli
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- muscle spasticity
- botulinum toxins
- diagnostic imaging
- nerve blocks
- diagnostic techniques