Special Issue "Recent Advances in Etiology of Shiga Toxins"
Deadline for manuscript submissions: 28 February 2022.
2. Environmental Diseases Research Center, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahak-ro, Daejeon 34141, Korea
Interests: Bacterial toxins; Shiga toxin-producing E.coli; Shiga toxins; hemolytic uremic syndrome
Special Issues and Collections in MDPI journals
Shigellosis, caused by Shiga toxin (Stx)-producing Shigella dysenteriae serotype 1 or Stx-producing Escherichia coli (STEC), continues to be a major public health threat and is a particular concern because of the potential to develop life-threatening extra-intestinal complications such as acute renal failure (hemolytic uremic syndrome (HUS)) and CNS complications such as seizures, paralysis, and death. Once Shiga toxins (Stxs) are internalized following toxin-receptor binding on the host cellular surface, they are trafficked into the Golgi apparatus and to the ER in a retrograde manner in order to enter the host cell cytosol, leading to various host cellular responses, including protein synthesis inhibition and apoptosis through ER stress, autophagy, and inflammation. The distinct investigations into the host cell signaling responses activated by Stxs as multi-functional proteins will be necessary in order to identify novel targets for intervention in the pathogenesis. Moreover, many studies present compelling and strong evidence about therapeutic applications in order to target particular diseases, such as tumors, by engineering the toxins.
At a molecular, cellular, and clinical level, an improved understanding of the pathogenesis bacillary dysentery and hemorrhagic colitis, as well as the subsequent development of extra-intestinal/extra-renal complications caused by STEC, will be necessary in order to develop effective protective and interventional therapies to treat patients infected with the organism.
This Special Issue of Toxins will focus on recent advances in the etiology of Shiga toxins in order to consider the unexplored mechanisms of toxin-mediated pathogenesis, current therapeutic applications, or the STEC genetics contributing to its pathogenicity.
Prof. Dr. Moo-Seung Lee
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Shiga toxins
- Shiga toxin-producing Shigella species
- Shiga toxin-producing Escherichia coli
- hemolytic uremic syndrome
- Shiga toxin-mediated pathogenesis
- cancer therapeutics
- toxin engineering