Special Issue "New Frontiers in Pore-Forming Toxins and Related Proteins: Molecular Mechanisms, Functions and Applications"
Deadline for manuscript submissions: closed (30 September 2021).
Interests: Pore-Forming Toxins
Pore-forming proteins (PFPs) are a large and structurally heterogeneous group of proteins that have the common ability to punch holes in the membrane. Amongst them, pore-forming toxins (PFTs) use this function to attack their host and represent some of the most potent virulence factors found in nature. PFTs share structural and mechanistic similarities with small host defense peptides (or antimicrobial peptides, AMPs) and other large endogenous PFPs that permeabilize membranes as part of host defense mechanisms against microorganisms or as components of regulatory signaling pathways in plants and animals. The general mode of action of these proteins and peptides involves membrane binding and insertion, oligomerization and eventually pore formation. Pore opening is usually lethal for the cell. However, despite these similarities, the sequence of events and detailed mechanisms how oligomeric structures assemble and form pores is highly variable from protein to protein and still obscure in several aspects. On a functional level, why did nature develop different ways of piercing membranes to kill a cell? Do different mechanisms of pore formation and different pore structures define different functionalities? Is cell death the unique consequence of membrane permeabilization? Which are the consequences of the sub-lytic action of these molecules? Understanding how membrane permeabilization is regulated holds a significant therapeutic potential to control this process in different biological processes such as infection, host defense, immunity and cell death. In this Special Issue we will welcome both reviews and research articles to provide an overview of the current knowledge about the molecular mechanisms and broad function of membrane pore formation for different proteins and peptides. Further studies on the biomedical applications of these proteins and peptides, as well as on the use of new state-of-art techniques that facilitate the characterization of membrane pores, are also encouraged.
Dr. Uris Ros
Dr. Katia Cosentino
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- pore-forming proteins
- pore-forming toxins
- antimicrobial peptides
- membrane pores
- virulence factors
- host-defense mechanisms
- cell death