Special Issue "Mycotoxin Biomarkers: Innovation and Utility"

A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Mycotoxins".

Deadline for manuscript submissions: 28 February 2022.

Special Issue Editors

Dr. Mark W. Sumarah
E-Mail Website
Guest Editor
Agriculture and Agri-Food Canada, Edmonton, Canada
Prof. Dr. J. David Miller
E-Mail Website
Guest Editor

Special Issue Information

Dear Colleagues,

The early epidemiology studies of aflatoxin exposure and liver cancer provided conflicting results. By the late 1980s, the need for a biomarker was apparent, notably to understand the attributable risk of disease. The pioneering work by Professors Chris Wild and John Groopman provided useful information on aflatoxin exposure by measuring the aflatoxin–lysine adduct in serum samples. This led to the production of the seminal papers on liver cancer in relation to aflatoxin exposure in Southern China. Reliable biomarkers of exposure for the other agriculturally important mycotoxins, namely fumonisin B1, deoxynivalenol, zearalenone and ochratoxin A, remain a challenge. Barriers include an understanding of the toxicokinetics of these four toxins in humans across a range of exposures and the impact of nutrition on interpreting the data. Further challenges include the availibilty and purity of isotopically labelled standards and improvement in the sensitivity of the analytical methods to allow smaller samples to be collected from study participants.

This Special Issue will explore the progress that has been made in the past and the current state of the art in this important area of research in a variety of contexts.

Dr. Mark W. Sumarah
Prof. Dr. J. David Miller
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • aflatoxin
  • fumonisin
  • deoxynivalenol
  • zearalenone
  • ochratoxin
  • mycotoxin
  • biomarker

Published Papers (1 paper)

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Volumetric Absorptive Microsampling as an Alternative Tool for Biomonitoring of Multi-Mycotoxin Exposure in Resource-Limited Areas
Toxins 2021, 13(5), 345; https://0-doi-org.brum.beds.ac.uk/10.3390/toxins13050345 - 11 May 2021
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Biomonitoring of biological samples arises as an effective tool to evaluate the exposure to mycotoxins in the population. Owing to the wide range of advantages, there is a growing interest in the use of non- and minimally invasive alternative sampling strategies, such as [...] Read more.
Biomonitoring of biological samples arises as an effective tool to evaluate the exposure to mycotoxins in the population. Owing to the wide range of advantages, there is a growing interest in the use of non- and minimally invasive alternative sampling strategies, such as dried blood spot sampling or volumetric absorptive microsampling (VAMS). A VAMS-based multi-mycotoxin method was developed and validated for 24 different mycotoxins. Method validation was based on the Bioanalytical Method Validation Guideline of the Food and Drug Administration from the United States and for most of the studied mycotoxins, the results of the performance characteristics were in agreement with the criteria of the European Commission Decision 2002/657/EC. The recovery for the different mycotoxins was not haematocrit dependent and remained acceptable after storing the VAMS for 7 and 21 days at refrigeration temperature (4 °C) and room temperature, demonstrating that VAMS could be applied to assess mycotoxin exposure in blood in resource-limited areas, where there may be a delay between sampling and analysis. Finally, a comparison between VAMS and a procedure for liquid whole blood analysis, performed on 20 different blood samples, did not result in missed exposed cases for VAMS. Moreover, both methods detected similar levels of ochratoxin A, ochratoxin alpha, zearalenone and aflatoxin B1. Given all the benefits associated with VAMS and the developed method, VAMS sampling may serve as an alternative to conventional venous sampling to evaluate multiple mycotoxin exposure. Full article
(This article belongs to the Special Issue Mycotoxin Biomarkers: Innovation and Utility)
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