Special Issue "Innovative Mycotoxin Detoxification: Discoveries, Mechanisms and Applications"

A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Mycotoxins".

Deadline for manuscript submissions: 31 December 2021.

Special Issue Editor

Dr. Ting Zhou
E-Mail Website
Guest Editor
Guelph Research and Development Center, Agriculture and Agri-Food Canada, Guelph, ON N1G 5C9, Canada
Interests: mycotoxin detoxification; microbial detoxification; trichothecene mycotoxins; deoxynivalenol; patulin
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Although great achievements have been made in controlling crop diseases caused by mycotoxigenic fungi, the fact is that mycotoxin contamination still cannot be avoided under the current agricultural practices. Moreover, the genetic alterations in some mycotoxigenic fungal populations have escalated the levels of mycotoxin contamination, and climate changes have already shown in certain geographic areas to possibly increase both the prevalence and severity of major mycotoxins. Globally, more than six hundred million metric tons of grains alone may be contaminated with various mycotoxins annually based on the FAO estimate of 25% mycotoxin contamination and the data of grain production worldwide. The contaminated grains and other food commodities present an ongoing safety burden in food supply chains, intensify food insecurity, add more challenges in environment protection, and cause substantial economic losses directly or indirectly. Therefore, postharvest strategies to mitigate mycotoxin contamination are truly essential and extremely critical. One such strategy is detoxification, which has shown very promising results in many studies and is attracting more and more researchers and industrial developers.

This Special Issue aims to provide an effective platform for 1) reporting discoveries of innovative mycotoxin detoxifications, including scientific concepts, novel technologies, and new organisms and agents, etc.; 2) illustrating understandings of detoxification mechanisms; and 3) demonstrating application possibilities and technologies. Both research (in particular) and review articles are welcome. We expect that the Special Issue will turn out to be a comprehensive and systematic compendium in the field of mycotoxin detoxification.

Dr. Ting Zhou
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • mycotoxin
  • detoxification
  • transformation
  • degradation
  • metabolite
  • toxicology
  • pathway
  • modeling
  • microorganisms
  • enzyme
  • food safety
  • feed safety

Published Papers (1 paper)

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A Novel Microbial Zearalenone Transformation through Phosphorylation
Toxins 2021, 13(5), 294; https://0-doi-org.brum.beds.ac.uk/10.3390/toxins13050294 - 21 Apr 2021
Viewed by 626
Zearalenone (ZEA) is a mycotoxin widely occurring in many agricultural commodities. In this study, a purified bacterial isolate, Bacillus sp. S62-W, obtained from one of 104 corn silage samples from various silos located in the United States, exhibited activity to transform the mycotoxin [...] Read more.
Zearalenone (ZEA) is a mycotoxin widely occurring in many agricultural commodities. In this study, a purified bacterial isolate, Bacillus sp. S62-W, obtained from one of 104 corn silage samples from various silos located in the United States, exhibited activity to transform the mycotoxin ZEA. A novel microbial transformation product, ZEA-14-phosphate, was detected, purified, and identified by HPLC, LC-MS, and NMR analyses. The isolate has been identified as belonging to the genus Bacillus according to phylogenetic analysis of the 16S rRNA gene and whole genome alignments. The isolate showed high efficacy in transforming ZEA to ZEA-14-phosphate (100% transformation within 24 h) and possessed advantages of acid tolerance (work at pH = 4.0), working under a broad range of temperatures (22–42 °C), and a capability of transforming ZEA at high concentrations (up to 200 µg/mL). In addition, 23 Bacillus strains of various species were tested for their ZEA phosphorylation activity. Thirteen of the Bacillus strains showed phosphorylation functionality at an efficacy of between 20.3% and 99.4% after 24 h incubation, suggesting the metabolism pathway is widely conserved in Bacillus spp. This study established a new transformation system for potential application of controlling ZEA although the metabolism and toxicity of ZEA-14-phosphate requires further investigation. Full article
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