Special Issue "Exposure to Ochratoxin A: Detection, Mitigation and Mechanisms of Toxicity"

A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Mycotoxins".

Deadline for manuscript submissions: closed (31 August 2021).

Special Issue Editor

Prof. Dr. Richard A. Manderville
E-Mail Website
Guest Editor
Department of Chemistry and Toxicology, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
Interests: DNA damage by phenolic toxins including ochratoxin A; Modified DNA bases as fluorescent probes
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

In the seminal paper published in Nature, 1965, van Der Merwe, Steyn, Fourie, Scott and Theron, reported the isolation of a new toxic metabolite, called ochratoxin A (now abbreviated OTA), from Aspergillus ochraceus. The mycotoxin contains a chlorophenolic moiety amide-linked to L-phenylalanine and exhibits strong blue fluorescence, which has played a key role in self-signaling detection of OTA in complex matrices.   Experimental carcinogenicity studies in rodent models carried out in the 1980s demonstrated OTA to be a potent kidney carcinogen.  OTA is regarded as the most toxic member of the ochratoxins, which have attracted considerable attention since they are one of the most abundant food-contaminating mycotoxins in the world and are classified as potentially carcinogenic to humans (Group 2B). Ongoing interdisciplinary research on the ochratoxins have been concerned with detection in feed and human foodstuff, occurrence and estimation of dietary and inhalation intake, establishment of limits for human consumption based on risk assessment, understanding mechanisms of toxicity for the development of detoxification processes and determining the toxic effects of OTA in the presence of other mycotoxins. Recent highlights in OTA research include the development of aptasensor-based platforms that eliminate the need for complex instrumentation to deliver rapid, on-site detection, and formation of new OTA bioconjugates for immunodiagnostics.  We hope that this collection of Toxins entitled “Exposure to Ochratoxin A: Detection, Mitigation and Mechanisms of Toxicity” will provide the readership with a better understanding of the key issues being addressed at the present time.

Prof. Dr. Richard A. Manderville
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Ochratoxin A (OTA)
  • OTA occurrence
  • OTA detection
  • OTA mitigation
  • risk assessment
  • OTA biosynthesis

Published Papers

There is no accepted submissions to this special issue at this moment.
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