Special Issue "Pore-Forming Toxins (PFTs): Never Out of Fashion"
A special issue of Toxins (ISSN 2072-6651).
Deadline for manuscript submissions: closed (31 May 2019).
Pore-forming toxins (PFTs) are ubiquitous peptides and proteins present in a wide variety of organisms, from prokaryotes to multicellular eukaryotes. Given their toxic character, they abound in venoms. Usually produced as water-soluble components, they suffer different conformational and oligomerization arrangements to become integral membrane structures, forming a pore. Typically, this pore leads to the death of the target cell by osmotic shock. Although most of them share a general mode of action, there is still much to learn about the particulars of their mechanism. Some PFTs recognize specific protein membrane receptors to achieve their action, but many others take advantage of the different membrane composition among organisms and/or cellular organelles. Accordingly, in many instances, PFTs target specific lipids such as sphingomyelin or cholesterol. Overall, further understanding PFTs molecular mechanisms will expand the available repertoire of pharmacological and biotechnological tools and will help to improve our knowledge of venoms composition and envenomation.
Prof. Dr. Alvaro Martínez-del-Pozo
Dr. Sara García Linares
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Ion channel
- Lipid rafts
- Membrane-protein interactions