Special Issue "Bacterial Pore-Forming Toxin"
Deadline for manuscript submissions: 30 November 2021.
Interests: bacterial pore-forming toxins; structure; function; evolution; regulation of toxin gene expression; monoclonal antibodies
The presence of direct evidence of the distribution of pathogenic microorganisms resistant to a wide range of antibiotics and the effective horizontal transfer of resistance genes to them has led to a situation in which antibiotics do not always help to cope with the infection. This requires the development of new approaches in the fight against bacterial infections. The study of the regulation of the expression of bacterial toxins is a basis for the implementation of directed control of the pathogenesis process. Finding ways to disrupt the adaptation of bacteria to various conditions and/or to hinder the expression of toxins, their secretion from the bacterial cell, and the implementation of separate stages of pore formation is certainly urgent. Therefore, a detailed knowledge of the principles of pore formation from genes to obtaining a mature pore makes it possible to determine the places of possible restriction or complete blocking of both the expression of genes of such toxins and their functional activity. Hence, it makes it possible to create an alternative anti-virulent therapy for many diseases, the course of which is determined by bacterial pore-forming toxins. The development of anti-virulence approaches will make it possible to obtain an alternative treatment for bacterial infections by acting directly on pathogenic factors, and not on a pathogenic microorganisms, including the design of monoclonal antibodies, toxin-specific antibodies, and small-molecule inhibitors against pore-forming proteins.
This current Issue is specifically focused on publishing research activities towards developing novel strategies for the diagnosis and suppression of pore-forming toxins. The Issue is expected to publish original research articles, reviews, and short communications in the broad area of pore-forming toxins research.
Dr. Alexander Solonin
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- anti-virulence therapy
- bacterial pore-forming toxins
- monoclonal antibodies
- toxin expression regulation