Special Issue "Mode of Action of Proteinaceous Toxins Produced by Bacillus thuringiensis"

A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Bacterial Toxins".

Deadline for manuscript submissions: 28 February 2022.

Special Issue Editor

Dr. Haruka Endo
Guest Editor
Department of Integrated Bioscience, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan
Interests: what is happening on the cell membrane from toxin-receptor interactions to pore formation; what the essence is of being a toxin receptor mediating high toxicity; co-evolution between cry toxins and host ABC transporters

Special Issue Information

Dear Colleagues,

Bacillus thuringiensis (Bt) produces a diversity of proteinaceous toxins, some of which are widely used for pest control in agriculture. The discovery of ABC transporters serving as receptors for Cry1A, Cry2A, and Cry3 toxins in the 2010s served as a breakthrough in research into mode of action of Cry toxin. In particular, key receptors for Cry1A toxins seem to be almost here. However, we are still far from an essential understanding of how Cry toxins form pores in the insect cell membrane via interactions with receptors. With regard to the remaining ~70 classes of Cry toxins, Vip toxins, and other Bt toxins, their receptors have not been identified or more research is needed to determine the role of receptor candidates.

The aim of this Special Issue is to provide seeds that will generate the next breakthrough in Bt research toward a complete understanding of the mode of action of Bt toxins. For that purpose, groundbreaking findings supported by a limited set of experiments are welcome. Negative results confirming or conflicting with previous reports are also welcome. Topics are not limited to receptor interaction but include the whole aspect of the mode of action (see Keywords). I look forward to your contribution.

Dr. Haruka Endo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Proteinaceous toxins from Bt
  • Toxin–receptor interaction
  • Mechanism of cell death
  • Mechanism of resistance
  • Insecticidal spectrum and specificity
  • Evolution and diversity of toxins
  • Factors affecting Bt susceptibility
  • Host responses to toxin attack
  • Strategy and engineering for application

Published Papers

This special issue is now open for submission.
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