Special Issue "Animal Poisons and Venoms in Drug Discovery"
Deadline for manuscript submissions: 31 December 2021.
Interests: Pharmacology; Toxicology; Ion channels; Electrophysiology; Kidney diseases, Hypertension, Cardiovascular function
2. Zoology Department, Faculty of Science, Minia University, El-Minia 61519, Egypt
Interests: animal venoms and toxins; drug discovery; ion channels and membrane receptors; electrophysiology; pharmacology; snakebite; antivenom production
The development of new drugs represents one of the biggest challenging activities of the pharmaceutical industry. Since the middle of the 20th century, a growing number of potential therapeutic agents have been extracted and isolated from plants, animal venoms, and microorganism toxins. While the preliminary effort with regard to animal poisons and venoms was to understand the effects of snake and spider bites and scorpion stings on humans and to elaborate the action of the toxins, toxins from animal poisons and venoms display wide-ranging pharmacological activities, targeting mainly ion channels, membrane receptors, and components of the hemostatic system with high selectivity and affinity. Animal poisons and venoms are complex chemical mixtures of biologically active proteins. Animal venom components were also understood to be medical tools for thousands of years in Ayurveda, homeopathy, and traditional/folk medicine for the treatment of a variety of pathophysiological conditions.
In the past few decades, several potential drugs in use or in clinical trials have been isolated or derived from animal venoms. Since 1981, 10 toxin-based molecules have received FDA approval, five from snakes (Captopril, Tirofiban, Eptifibatide, Batroxobin, and Cobratide), two from lizards (Exenatide and Lixisenatide), two from leeches (Bivalirudin and Desirudin), and one from cone snails (Ziconotide). Many additional animal venom components are also currently in different clinical stages as therapeutic drugs.
This Special Issue of Toxins on “Animal Poisons and Venoms in Drug Discovery” aims to provide a comprehensive view not only of snake venom but also several other animal toxins having therapeutic potential for drug discovery. We welcome all research including original research articles, reviews, and short communications focused on the characterization, pharmacology, and therapeutic applications of animal poisons and venoms and their subcomponents. We hope that researchers will share their valuable studies using snake venoms for drug development.
Dr. Antonio Garcia Soares
Dr. Tarek Mohamed Abd El-Aziz
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Animal poisons and venoms
- Bioactive proteins and peptides
- Drug discovery
- Therapeutic applications
- Ion channels
- Membrane proteins
- Antimicrobial agents