Special Issue "Structure and Function of Clostridial and Botulinum-Like Neurotoxins"
Deadline for manuscript submissions: 15 December 2021.
Members of the clostridial neurotoxins are the most poisonous protein toxins known to man, and the causative agents of the potentially fatal diseases tetanus and botulism. This family of potent toxins has recently witnessed rapid expansion beyond the tetanus toxin (TeNT) and seven serotypes and over forty subtypes that have classically defined the botulinum neurotoxins (BoNTs). This includes potential novel BoNT serotypes and natural chimeric proteins with mixed types whose biochemical and pharmacological properties are being investigated. In addition, with advances in high-throughput genomics technology, environmental samples have revealed new BoNT-like proteins, particularly in non-clostridial bacterial species. Determining the function and potency of these new toxins is essential to ensuring they do not pose any biological threats in addition to assessing their potential for biotechnological use. Whilst the main function of BoNTs is well defined, as they specifically target neuromuscular junctions resulting in inhibition of neurotransmission and causing paralysis, the species selectivity and effect of new toxins on their target―which is unknown in some cases―is not evident. Determining the structure and activity of these toxins and homologues will provide important information to understanding their evolution, and how they have developed specific host interactions. It will also provide a basis for the development of novel biotechnological tools that can extend how this family of toxins can be used beyond the current BoNT therapeutic applications.
This Special Issue “Structure and Function of Clostridial and Botulinum-Like Neurotoxins” aims to bring together the latest research on the biochemical properties and function of BoNTs, their newly identified homologues, and of proteins associated with their toxicity.
Dr. Geoffrey Masuyer
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- clostridial toxins
- bacterial toxins
- protein engineering
- protein structure