Special Issue "Bacterial Secretion Systems, Anti-host Effectors and Toxins: Towards the New Microbiology"

A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Bacterial Toxins".

Deadline for manuscript submissions: 31 December 2021.

Special Issue Editor

Dr. Abderrahman Hachani
Guest Editor
University of Melbourne, Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity. Melbourne, Australia

Special Issue Information

In recent years, the study of molecular mechanisms driving bacterial pathogenesis has significantly advanced our understanding of eukaryotic cell biology. Bacteria have evolved a diverse array of secretion systems (SS) devoted to protein transport. To date, up to ten types of secretion systems have been identified (TISS-TXSS), differing in their composition, biogenesis, organization, function and dynamic.

These complex machineries span bacterial membranes to transport their cargo from the bacterial cytosol to the external milieu or to directly inject them into targeted host cells.  These proteins, called effectors, target various host cellular pathways to affect or antagonize antibacterial host responses to bacterial pathogen infection.

In this Special Issue, we seek contributions focusing on the most recent advances made in the field of bacterial secretion systems and anti-host effectors. We strongly encourage the submission of manuscripts providing a critical review of the current landscape of bacterial secretion systems and their cognate effectors, in light of the new developments in effector biology and the technical limitations hampering these progresses. We also welcome mechanistic studies delineating the role of bacterial effectors during host infection.

Finally, we are encouraging the submission of manuscripts reviewing emerging technologies harnessing the biochemical activities of effectors, methodologies facilitating the discovery of new effectors from bacterial genome mining; and the use of alternative infection models facilitating the functional characterization of effectors in pathogenesis.

Dr. Abderrahman Hachani
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Bacterial Secretion Systems
  • Effectors
  • Cell biology
  • Cell autonomous immunity
  • Host-pathogen interactions
  • Toxins
  • Alternative infection models
  • Genomics

Published Papers

This special issue is now open for submission, see below for planned papers.

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Calcium Signalling in Anti-Bacterial Cell Intrinsic Immunity
Authors: Joseph J Wanford and Charlotte Odendall
Affiliation: 1) School of Immunology and Microbial Sciences, Kings College London, London, UK
Abstract: Almost all eukaryotic cellular processes are directly or indirectly modulated by calcium ions (Ca2+), spanning from cytoskeletal organization to metabolism. A key role of Ca2+ in multicellular organisms is the regulation of innate and adaptive immunities. Despite the critical and widespread role of Ca2+ in immune functions, there is a paucity of data on its role in the regulation of anti-bacterial cell intrinsic immunity. In this review we describe the role of Ca2+signalling in bacterial pattern recognition, the activation of immune signalling cascades and the initiation of programmed cell death. Further, we discuss recent work describing the evolution of virulence factors in bacteria to modulate Ca2+ signalling to facilitate pathogenesis, and the subsequent implications for the development of novel therapeutics.

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