Special Issue "Uremic Metabolites"

A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Uremic Toxins".

Deadline for manuscript submissions: 30 November 2021.

Special Issue Editor

Dr. Terence Ryan
E-Mail Website
Guest Editor
Department of Applied Physiology & Kinesiology, University of Florida, Gainesville, FL 32611, USA
Interests: mitochondria; bioenergetics; redox biology; skeletal muscle; cardiovascular disease

Special Issue Information

Dear Colleagues,

A major function of the kidneys is to rid the body of waste materials that are either ingested or produced endogenously by normal metabolism. Impaired kidney function leads to the retention of waste products, termed uremic toxins, which can be harmful/toxic to numerous tissues/organs. Several uremic toxins have been strongly linked to cardiovascular and all-cause mortality in patients with renal insufficiency. Studies have also demonstrated pathological effects of these uremic toxins in numerous cell and tissue types. Despite what has been discovered, there is still very little known about the numerous mechanisms linking uremia to the pathogenesis of disease. Further to this, advancements in metabolomics technology have pushed the field to the precipice of identifying new uremic toxins with deleterious effects. This Special Issue will focus on publishing and highlighting original research articles and reviews on uremic toxicity, including their harmful effects in cells, tissue, animals, and patients, as well as cellular mechanisms of pathogenesis and novel therapeutics to ameliorate the effects of uremic toxins.


Dr. Terence Ryan
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • uremia
  • kidney disease
  • toxins
  • cardiovascular disease
  • metabolism
  • renal
  • dialysis
  • metabolomics
  • organic metabolites

Published Papers

This special issue is now open for submission.
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