Special Issue "The Two-Fold Role of Uremic Retention Molecules as Toxins and Signaling Molecules"

A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Uremic Toxins".

Deadline for manuscript submissions: 31 March 2022.

Special Issue Editors

Prof. Dr. Jerome Lowenstein
E-Mail Website
Guest Editor
Renal Division, Department of Medicine New York University Langone Medical Center, 560 First Avenue New York, NY 10016, USA
Prof. Dr. Björn Meijers
E-Mail Website
Guest Editor
1. Laboratory of Nephrology, Department of Immunology and Microbiology, KU Leuven—University of Leuven, B-3000 Leuven, Belgium;
2. Department of Nephrology and Renal Transplantation, University Hospitals Leuven, B-3000 Leuven, Belgium
Interests: uremic toxicity; protein-bound toxins; chronic kidney disease; hemodialysis; blood purification; P-cresol sulphate; indoxyl sulphate

Special Issue Information

Dear Colleagues,

While nephrologists have been conditioned to think in terms of uremic “toxins”, this traditional view is challenged by a number of observations. First, most uremic toxins and uremic solutes are present in the body in the absence of kidney dysfunction. In addition to OATs, there are transporters of these small molecules in many non-renal tissues. One possibility, consistent with a growing amount of biochemical and molecular data, is that so-called uremic toxins, while harmful when in excess in the setting of kidney failure, might have other important “non-toxic” roles in normal biology, including metabolism, signaling, regulating redox state, and gut microbiome population dynamics.

Prof. Dr. Jerome Lowenstein
Prof. Dr. Björn Meijers
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • uremic retention solutes
  • organic anion transporters
  • sensing and signaling
  • aryl hydrocarbon receptor
  • EGF receptor

Published Papers

This special issue is now open for submission.
Back to TopTop