Special Issue "Effects of Single and Combined Mycotoxins"
Deadline for manuscript submissions: 31 October 2021.
Fungi from the Aspergillus, Fusarium, and Penicillium genera are principal producers of mycotoxins that contaminate foodstuffs worldwide. The mycotoxin producers can co-occur in food substrates, and some species can simultaneously produce several mycotoxins, altogether elevating the risk of human and animal co-exposure to multiple mycotoxins. From a public health point of view, the most important foodborne mycotoxins are aflatoxins (AFs), fumonisins (FBs), trichothecenes (including deoxynivalenol (DON) and T-2 and HT-2 toxins), ochratoxin A (OTA), patulin (PAT), and zearalenone (ZEN). The maximum levels of the major mycotoxins have been set in the legislation of many countries and trade zones over the world; in the European Union, the legislation has been harmonized. Analytical methods based on liquid chromatography tandem mass spectrometry (LC-MS/MS) have enabled multiple mycotoxin detection, including major mycotoxins, masked and modified mycotoxins (e.g., DON and ZEN derivates), as well as emerging mycotoxins (enniatins-ENN, beauvericin-BEA, and fusaproliferin-FUS, and moniliformin-MON). An increasing number of publications in recent years have pointed out that binary, tertiary, and multiple mycotoxin mixtures in vitro and in vivo could result in interaction effects classified into three major types: antagonistic, additive, and synergistic. The type of interactions is influenced by multiple parameters, including the type of mycotoxin in the mixture and their concentration, duration of exposure, type of biological experimental model, toxicological endpoint, and mathematical model used to evaluate mycotoxin interaction. This Special Issue of Toxins aims to gather contributions of original research or review papers that will indicate different perspectives and addressing the problems in exposure risk assessment to mycotoxins mixtures.
Prof. Maja Šegvić Klarić
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- mycotoxin mixtures
- mycotoxin interactions
- combined toxicity
- cell lines
- human and animal health