Conotoxins: Characterization, Pharmacology, and Therapeutics
A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Marine and Freshwater Toxins".
Deadline for manuscript submissions: closed (31 December 2019) | Viewed by 7777
Special Issue Editor
Interests: conotoxins; Veratrum alkaloids; chemistry and bioactivity of natural products from marine and terrestrial sources; food and dairy chemistry
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Conotoxins have been studied extensively for use as therapeutic drugs to treat pain, neurological disorders, and a variety of common ailments. FDA approval of the drug Ziconotide in 2004 demonstrated the potential for conotoxins to be used in native form for the treatment of chronic pain. These small peptides selectively target biological receptors and exhibit some of the most intense responses observed from any natural product.
In this Special Issue, papers are sought that contribute to the wealth of information regarding conotoxin sequence, structure, and activity characterization, demonstrate bioactivity evaluation methods to assess conotoxin pharmacological response, and describe potential peptide candidates for therapeutic applications. Submissions are encouraged from groups that report native peptide discovery, synthetic peptide experimentation, and computationally designed conotoxin analogues. Modern strategies for evaluating conotoxin pharmacology and innovative systems for studying activity and receptor binding are anticipated.
Prof. Dr. Owen M. McDougal
Guest Editor
Manuscript Submission Information
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Keywords
- conotoxin
- structure activity relationship
- nicotinic acetylcholine receptor
- mutational analysis
- positional scanning synthetic combinatorial libraries
- bioactivity characterization
- therapeutic applications