Special Issue "Evolutionary Features of Bacterial Toxins for Their Structure–Function Development"

A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Bacterial Toxins".

Deadline for manuscript submissions: 1 December 2021.

Special Issue Editors

Dr. Bal Ram Singh
E-Mail Website1 Website2
Guest Editor
Botulinum Research Center, Institute of Advanced Sciences, North Dartmouth, MA 02747, USA
Interests: protein toxins; structure–function of proteins; detection; vaccine development; antidote development
Dr. Raj Kumar
E-Mail Website1 Website2
Guest Editor
Botulinum Research Center, Institute of Advanced Sciences, North Dartmouth, MA 02747, USA
Interests: biomolecular spectroscopy; protein folding and dynamics; cellular biology; molecular dynamics simulation; protein NMR and neuroscience

Special Issue Information

Dear Colleagues,

The basis of life on our planet is widely believed to be due to the biological evolution. The main reason for diversity is genetic variation coupled with random mutations. In other words, gene products, proteins, and other structural and functional biomolecules are largely responsible for producing diversity, promoting adaptational, and facilitating natural selection under a continuously changing environment. However, several questions remain unanswered, such as a) the main driving force of evolution (i.e., the basis of evolutionary pressure), b) why there is a variation in the rate of evolution, and c) the molecular mechanism of evolution. In view of these questions, a consideration of the physicochemical and molecular basis of mutation and the linking molecular mechanism of evolution are important. One potential approach could be to identify a group of molecules which should be able to connect structure and function to evolutionary conserved processes in the host. A group of interesting molecules to consider for this exercise is that of bacterial toxins. Bacterial toxins are a special group of highly evolved molecules which are involved in toxication as well as the survival of organisms. They are used as poison as well as therapeutic molecules, and interestingly, they use evolutionarily conserved biological processes of the host to execute their biological function.

Structurally, these molecules are uniquely designed and incorporate domains to construct highly effective biological molecules.

This issue will aim to incorporate the structural and functional features of bacterial toxins and put forward their unique evolutionary features.

Dr. Bal Ram Singh
Dr. Raj Kumar
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • bacterial toxins
  • biological function
  • co-evolution
  • evolution
  • genomic size
  • molecular flexibility
  • multifunctionality
  • mutation rates
  • protein dynamics
  • target hosts

Published Papers

This special issue is now open for submission.
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