Special Issue "Neurophysiology of Botulinum Toxins in Clinical Practice"
Deadline for manuscript submissions: 31 January 2022.
Botulinum neurotoxin (BoNT) is one of the most powerful toxins in nature, and is a polypeptide produced by different serotypes of the bacterium (Clostridium botulinum) that are now well identified. Serotypes A and B are largely used in clinical practice to treat different neurological diseases characterized by neuromuscular hyperactivity, autonomic dysfunction, pain syndrome, and so on.
The electrophysiological effects of BoNT have been investigated in systemic human botulism, where the most commonly used tests include the evaluation of variations in compound muscle action potentials (CMAPs), repetitive nerve stimulation, and single-fiber EMG (SFEMG), However, in clinical practice the role of neurophysiology is still unclear, making it difficult to evaluate the neuromuscular block induced by different BoNT serotypes. Therefore, the role of electrophysiology during therapeutic BoNT injections in clinical practice is controversial.
In the literature, the utility of neurophysiology to evaluate the systemic spread of BTX in peripheral or central nervous systems following local injection has been reported, but how electrophysiology may help to check subtle changes in autonomic and nociceptive terminal endings is not well defined.
The aim of this Special Issue is to review the role of neurophysiology in BoNT poisoning in humans. Preliminarily, the electrophysiological findings in wound botulism will be reviewed . Then, the neurophysiological features of BoNT treatment will be revised for: improving the clinical strategy of BoNT injections; detecting local or systemic effects in the PNS and CNS; quantifying the effect of BoNTs on autonomic or nociceptive fibers; detecting adverse local or distant side effects and evaluating true BoNT-resistant subjects.
Prof. Dr. Roberto Eleopra
Manuscript Submission Information
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- botulinum toxins