Special Issue "Toxic Secondary Plant Metabolites: Toxicology, Medicine, Pharmacology, Ecotoxicology and Crop Protection"

A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Plant Toxins".

Deadline for manuscript submissions: 31 January 2022.

Special Issue Editors

Prof. Dr. Zbigniew Adamski
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Guest Editor
Department of Animal Physiology and Development / Electron and Confocal Microscope Laboratory, Faculty of Biology, Adam Mickiewicz University, Poznań, Poland
Interests: lethal and sub-lethal effects of plant-derived substances and their possible application as insecticides and nematicides; effects of alkaloids at cell and tissue level; alkaloid-procured lethality, altered fecundity and fertility, and morphological malformations of tested organisms
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Prof. Dr. Laura Scrano
E-Mail Website
Guest Editor
Dipartimento delle Culture Europee e del Mediterraneo, Università degli Studi della Basilicata, Potenza, Italy
Interests: pharmaceuticals from plants and microorganisms; chemistry of natural substances in vegetables and soil; plant secondary metabolites; mass spectrometry
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Prof. Dr. Sabino Aurelio Bufo
E-Mail Website
Guest Editor
Department of Science, University of Basilicata, Potenza, ItalyDepartment of Geography, Environmental Management & Energy Studies, University of Johannesburg, Johannesburg, South Africa
Interests: pharmaceuticals from plants and microorganisms; chemistry of natural substances in vegetables and soil; plant secondary metabolites; protection and recovery of ecosystems
Special Issues and Collections in MDPI journals
Prof. Dr. Piotr Klimaszyk
E-Mail Website
Guest Editor
Department of Water Protection, Institute of Environmental Biology, Faculty of Biology, Adam Mickiewicz University, Poznań, 61-614 Poznan, Poland
Interests: environmental toxicology; limnology and water pollution; food safety
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Plants, bacteria, and fungi produce numerous substances known under the common name of secondary metabolites. Although they differ in structure, chemical properties, and roles in organisms, they possess a common feature—they are not involved directly in producing or developing the producing organisms. Among secondary plant metabolites, one can find alkaloids, terpenoids, steroids, glucosinolates, phenolic compounds, tannins, and others.

The intensive research on plant secondary metabolites in the previous decades led to many significant results, showing the toxic but also therapeutic activity of these substances. Numerous researchers have indicated that these substances may be helpful in plant protection due to the exerted toxicity to pests and their diffused availability and low environmental persistence. Many studies showed that secondary plant metabolites are up-and-coming tools in pharmacology and medicine, as drugs used to treat various diseases, including parasitic diseases and cancers. As substances with toxic properties, they may disturb food webs and ecosystems.

Prof. Dr. Zbigniew Adamski
Prof. Dr. Laura Scrano
Prof. Dr. Sabino Aurelio Bufo
Prof. Dr. Piotr Klimaszyk
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • secondary metabolites
  • cyanobacteria
  • algae
  • plant toxins
  • biological activity
  • integrated pest management
  • plant medicine
  • pharmacological activity
  • functional characterization

Published Papers (1 paper)

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Research

Article
Solanum nigrum Extract and Solasonine Affected Hemolymph Metabolites and Ultrastructure of the Fat Body and the Midgut in Galleria mellonella
Toxins 2021, 13(9), 617; https://0-doi-org.brum.beds.ac.uk/10.3390/toxins13090617 - 01 Sep 2021
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Abstract
Glycoalkaloids, secondary metabolites abundant in plants belonging to the Solanaceae family, may affect the physiology of insect pests. This paper presents original results dealing with the influence of a crude extract obtained from Solanum nigrum unripe berries and its main constituent, solasonine, on [...] Read more.
Glycoalkaloids, secondary metabolites abundant in plants belonging to the Solanaceae family, may affect the physiology of insect pests. This paper presents original results dealing with the influence of a crude extract obtained from Solanum nigrum unripe berries and its main constituent, solasonine, on the physiology of Galleria mellonella (Lepidoptera) that can be used as an alternative bioinsecticide. G. mellonella IV instar larvae were treated with S. nigrum extract and solasonine at different concentrations. The effects of extract and solasonine were evaluated analyzing changes in carbohydrate and amino acid composition in hemolymph by RP-HPLC and in the ultrastructure of the fat body cells by TEM. Both extract and solasonine changed the level of hemolymph metabolites and the ultrastructure of the fat body and the midgut cells. In particular, the extract increased the erythritol level in the hemolymph compared to control, enlarged the intracellular space in fat body cells, and decreased cytoplasm and lipid droplets electron density. The solasonine, tested with three concentrations, caused the decrease of cytoplasm electron density in both fat body and midgut cells. Obtained results highlighted the disturbance of the midgut and the fat body due to glycoalkaloids and the potential role of hemolymph ingredients in its detoxification. These findings suggest a possible application of glycoalkaloids as a natural insecticide in the pest control of G. mellonella larvae. Full article
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