Special Issue "Toxins and Lung Infection"
A special issue of Toxins (ISSN 2072-6651).
Deadline for manuscript submissions: closed (4 November 2020).
The air-blood barrier in the lungs, formed by the alveoli together with the surrounding capillaries, is the primary exchange surface for the uptake of O2 from the alveolar space and the removal of CO2 from the blood. This vulnerable system requires that the alveoli remain relatively dry, as assured by vectorial sodium transport-driven alveolar liquid clearance, and that the alveolar-capillary barriers remain tight, regulated by adherens and tight junction proteins. Bacterial toxins are potent inducers of pulmonary inflammation and can impair alveolar fluid clearance, through vectorial sodium transport actions, and barrier function, through phosphorylation of tight and adherens junction proteins. These toxin actions can ultimately lead to lung disease, including acute lung injury and acute respiratory distress syndrome (ARDS). This Special Issue will focus on how G+/G- bacterial toxins, including the pore-forming toxins pneumolysin, listeriolysin-O, and alpha-toxin, as well as lipopolysaccharide (LPS), affect cellular processes involved in pathophysiology and resolution of lung disease and how their actions may be modulated. The reader will be provided with an overall view of what is presently known about the mode of action and functions of these toxins, and how they may be inhibited or even harnessed to promote the entry of other important biologically relevant proteins and substances.
Prof. Dr. Rudolf Lucas
Prof. Dr. Trinad Chakraborty
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.