Adjuvanted Influenza Vaccines

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Vaccine Adjuvants".

Deadline for manuscript submissions: closed (20 February 2022) | Viewed by 3599

Special Issue Editors


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Guest Editor
Department of Biotechnology, INIA-CSIC, 28040 Madrid, Spain
Interests: viral immunology; innate immunity; adaptive immunity; adjuvants; vaccines; immune pathways; fish immunology; rhabdovirus; virus-host interaction; RNA virus; DNA virus
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Boston Children's Hospital, Harvard Medical School, Boston, MA, USA
Interests: vaccines; adjuvants; inflammation; formulation; small molecules; antigen presenting cells; macrophages; dendritic cells, Immunology; pharmacology; vascular biology; molecular biology; cellular signaling pathways; kinases; phosphatase; TLR; MAPK; vaccine safety; influenza; SARS-CoV2; tissue culture
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Despite current influenza vaccines being immunogenic, the evolution of the influenza virus can reduce their efficacy, so influenza remains a major threat to public health. One approach to improving influenza vaccines is to include adjuvants. An immunologic adjuvant is defined as a substance that acts to accelerate, prolong, or enhance antigen-specific immune responses when used in combination with specific vaccine antigens. Adjuvants are particularly beneficial for influenza vaccines administered during a pandemic, when a rapid response is required or for use in patients with impaired immune responses. To date, six adjuvants have been used in licensed human vaccines: Alum, MF59, AS03, AF03, virosomes, and heat-labile enterotoxin (LT).

This issue will address the potential of novel adjuvant strategies to modulate innate and adaptive immune responses to facilitate the development of improved prophylactic or therapeutic vaccines. Submission of original articles and systematic reviews is welcome. Manuscripts will follow standard journal peer-review practices, and those accepted for publication will appear in the Special Issue, “Adjuvanted Influenza Vaccines”. We look forward to receiving and welcome your contributions.

Dr. Eduardo Gomez-Casado
Dr. Dheeraj Soni
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • adjuvant
  • vaccine
  • particulate adjuvant
  • innate immunity
  • adaptive immunity
  • nanoparticle
  • AS03
  • Alum
  • MF59
  • antibody
  • formulation

Published Papers (1 paper)

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Research

16 pages, 5011 KiB  
Article
Riboflavin as a Mucosal Adjuvant for Nasal Influenza Vaccine
by Yinyan Yin, Jinyuan Wang, Xing Xu, Bangyue Zhou, Sujuan Chen, Tao Qin and Daxin Peng
Vaccines 2021, 9(11), 1296; https://0-doi-org.brum.beds.ac.uk/10.3390/vaccines9111296 - 09 Nov 2021
Cited by 4 | Viewed by 2747
Abstract
Intranasal immunization with whole inactivated virus (WIV) is an important strategy used for influenza prevention and control. However, a powerful mucosal adjuvant is required to improve nasal vaccine efficacy. Riboflavin, as a food additive with the advantages of being safe and low-cost, widely [...] Read more.
Intranasal immunization with whole inactivated virus (WIV) is an important strategy used for influenza prevention and control. However, a powerful mucosal adjuvant is required to improve nasal vaccine efficacy. Riboflavin, as a food additive with the advantages of being safe and low-cost, widely exists in living organisms. In this paper, the mucosal adjuvant function of riboflavin was studied. After intranasal immunization with H1N1 WIV plus riboflavin in mice, we found that the mucosal immunity based on the secretory IgA (sIgA) levels in the nasal cavity, trachea, and lung were strongly enhanced compared with H1N1 WIV alone. Meanwhile, the IgG, IgG1, and IgG2a levels in serum also showed a high upregulation and a decreased ratio of IgG1/IgG2a, which implied a bias in the cellular immune response. Moreover, riboflavin strongly improved the protection level of H1N1 inactivated vaccine from a lethal influenza challenge. Furthermore, riboflavin was found to possess the capacity to induce dendritic cell (DC) phenotypic (MHCII, CD40, CD80, and CD86) and functional maturation, including cytokine secretion (TNF-α, IL-1β, IL-12p70, and IL-10) and the proliferation of allogeneic T cells. Lastly, we found that the DC maturation induced by riboflavin was dependent on the activation of the mitogen-activated protein kinase (MAPK) signaling pathway, which plays an important role in immune regulation. Therefore, riboflavin is expected to be developed as an alternative mucosal adjuvant for influenza nasal vaccine application. Full article
(This article belongs to the Special Issue Adjuvanted Influenza Vaccines)
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