Humanized Mice in Vaccinology: Opportunities and Challenges in 2021

Dear Colleagues,

Over the last decade, the use of mice harboring human cells, in particular human immune cells, has increased exponentially. The wide variety of available models with improved engraftment, mature, and functional human T and B cells and reduced graft vs. host disease has allowed one to study human-restricted pathogens and a variety of tumors as well as autoimmune diseases to an unprecedented detail. Importantly, some efforts have also been devoted to further develop models harboring not only human immune cells but also human peripheral cells from tissues with relevance in disease pathophysiology. A number of recent studies have also used humanized mice as in vivo platforms to test vaccine immunogenicity and protection.

In this Special Issue, we will discuss all aspects related to the use of humanized mice in vaccinology and discuss the opportunities and the challenges ahead.

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• humanized mice
• vaccine
• viruses
• cancer vaccines
• dendritic cell vaccines
• T cells
• emerging viruses
• persistent viruses
• immunogenicity
• NSG
• BLT
• uPA
• xenografts