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Journals
Vaccines
Special Issues
The Host Immune Defensive Response toward Microbes
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The Host Immune Defensive Response toward Microbes

A special issue of Vaccines (ISSN 2076-393X).

Deadline for manuscript submissions: closed (11 August 2022) | Viewed by 2366

Special Issue Editor

Dr. Federico Iovino

E-Mail Website
Guest Editor
Department of Neuroscience, Karolinska Institutet, Solnavägen 9, 171 65 Solna, Sweden
Interests: streptococcus pneumoniae; host–pathogen interaction; bacterial meningitis; blood–brain barrier and endothelial cells; neuroinflammation; microglia; neuronal damage
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Microorganisms are part of our life, and our immune system often trigger different reactions in response to microorganisms present in our body. Some microbes are commensal and colonize certain compartments of our body without causing any disease; however, they can often turn from harmless commensal into pathogenic. Other microbes, meanwhile, are intrinsically pathogenic. The aim of this Special Issue is to bring together research studies focused on the interplay between host immunity and microbes both in health and disease.

Dr. Federico Iovino
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • immune response
  • health and disease
  • commensal and pathogenic microbes

Published Papers (1 paper)

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Research

10 pages, 10257 KiB  
Article
Potential Antiviral Activity of Lactiplantibacillus plantarum KAU007 against Influenza Virus H1N1
by Irfan A. Rather, Majid Rasool Kamli, Jamal S. M. Sabir and Bilal Ahmad Paray
Vaccines 2022, 10(3), 456; https://0-doi-org.brum.beds.ac.uk/10.3390/vaccines10030456 - 16 Mar 2022
Cited by 5 | Viewed by 2087
Abstract
The development of antiviral resistance has exacerbated a growing threat to public health. As a result, there is increasing demand for unconventional antivirals that can effectively replace the presently in-use drugs. Lactic acid-producing bacteria (LAB) are among the most common bacteria used in [...] Read more.
The development of antiviral resistance has exacerbated a growing threat to public health. As a result, there is increasing demand for unconventional antivirals that can effectively replace the presently in-use drugs. Lactic acid-producing bacteria (LAB) are among the most common bacteria used in the food industry. These bacteria play an essential role in the fermentation of many foods and feed. Additionally, these bacteria are considered more economical, efficient, and safe “nutraceuticals” in the health care arsenal. Therefore, we carried out the screening and molecular characterization of raw camel milk LAB isolates and tested their inhibitory activity against influenza virus H1N1. The strain that exhibited the highest antiviral activity against the H1N1 virus, confirmed by hemagglutination assay, was identified as Lactiplantibacillus plantarum KAU007. The study also confirmed the non-cytotoxic behavior of CFCS isolated from KAU007 against MDCK cells, approving its safety concern against the mammalian cells. Besides, CFCS at 5 and 10 mg/mL significantly decreased the level of IFN-γ (p < 0.001 and p < 0.001) and IL-6 (p < 0.001 and p < 0.005) in a dose-dependent manner, respectively. This is a preliminary report about the anti-influenza activity of KAU007 isolated from camel milk. This study reinforces that camel milk contains beneficial LAB isolates with antagonistic properties against the H1N1 influenza virus. Full article
(This article belongs to the Special Issue The Host Immune Defensive Response toward Microbes)
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