From Fundamental Biology to Translational Medicine: Block Host-Pathogen Interaction to Prevent Onset of Infectious Diseases

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Vaccines against Infectious Diseases".

Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 3195

Special Issue Editor

Department of Neuroscience, Karolinska Institutet, Solnavägen 9, 171 65 Solna, Sweden
Interests: streptococcus pneumoniae; host–pathogen interaction; bacterial meningitis; blood–brain barrier and endothelial cells; neuroinflammation; microglia; neuronal damage
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Special Issue Information

Dear Colleagues,

The scope of this topic is to shed light into all those translational studies that use the knowledge of the mechanisms engaged by pathogens to interact with the host to develop novel therapeutic approaches that interfere with such mechanisms ultimately leading to prevention of invasive disease development.

Dr. Federico Iovino
Guest Editor

Manuscript Submission Information

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Keywords

  • Host-pathogen interaction
  • Novel therapeutic approaches
  • Prevention of invasive disease

Published Papers (1 paper)

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Review

15 pages, 809 KiB  
Review
The Stem Cell Revolution Revealing Protozoan Parasites’ Secrets and Paving the Way towards Vaccine Development
by Alena Pance
Vaccines 2021, 9(2), 105; https://0-doi-org.brum.beds.ac.uk/10.3390/vaccines9020105 - 31 Jan 2021
Cited by 5 | Viewed by 2678
Abstract
Protozoan infections are leading causes of morbidity and mortality in humans and some of the most important neglected diseases in the world. Despite relentless efforts devoted to vaccine and drug development, adequate tools to treat and prevent most of these diseases are still [...] Read more.
Protozoan infections are leading causes of morbidity and mortality in humans and some of the most important neglected diseases in the world. Despite relentless efforts devoted to vaccine and drug development, adequate tools to treat and prevent most of these diseases are still lacking. One of the greatest hurdles is the lack of understanding of host–parasite interactions. This gap in our knowledge comes from the fact that these parasites have complex life cycles, during which they infect a variety of specific cell types that are difficult to access or model in vitro. Even in those cases when host cells are readily available, these are generally terminally differentiated and difficult or impossible to manipulate genetically, which prevents assessing the role of human factors in these diseases. The advent of stem cell technology has opened exciting new possibilities to advance our knowledge in this field. The capacity to culture Embryonic Stem Cells, derive Induced Pluripotent Stem Cells from people and the development of protocols for differentiation into an ever-increasing variety of cell types and organoids, together with advances in genome editing, represent a huge resource to finally crack the mysteries protozoan parasites hold and unveil novel targets for prevention and treatment. Full article
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