Special Issue "Lymphoma in Animals"

A special issue of Veterinary Sciences (ISSN 2306-7381). This special issue belongs to the section "Clinical Veterinary Medicine".

Deadline for manuscript submissions: 31 December 2022.

Special Issue Editors

Prof. Dr. Massimo Vignoli
E-Mail Website
Guest Editor
Faculty of Veterinary Medicine, University of Teramo, Piano D'Accio, 64100 Teramo, Italy
Interests: oncology; ultrasound; surgical clinic; CEUS; computed tomography; interventional radiology
Special Issues, Collections and Topics in MDPI journals
Dr. Arianna Miglio
E-Mail Website
Guest Editor
Faculty of Veterinary Medicine, Veterinary University Hospital, University of Teramo, Piano d'Accio, 64100 Teramo, Italy
Interests: clinical pathology; hematology and hemato-oncology; transfusion medicine

Special Issue Information

Dear Colleagues,

The theme of this Special Issue of Veterinary Sciences is Lymphoma.

Lymphoma represents the most frequent hematopoietic cancer in animals and it shows significant overlap with the human disease. Its classification and grading schemes tend to reflect the analogous in people, by grouping lymphomas according to their cytological, clinical and morphological characteristics. Moreover, in human and veterinary medicine, the World Health Organization (WHO) classification system integrates knowledge of not only topography but also immunophenotype, genetic features and molecular aspects.

The scope of this Special Issue is to provide a source for the publication of articles, reviews, case reports, and case studies covering all aspects of this common neoplasm. Particularly, we encourage improving the knowledge and comparative aspects regarding diagnosis, prognosis and therapy in course of Lymphoma between different mammalian species, including humans. This Special Issue should encourage good contact between clinicians, pathologists, and oncologists to support daily work, scientific research, increase knowledge, and to facilitate coordination of clinical research in all species.

Constant work by experts in this area of interest is important so that knowledge can be extended both in terms of early and accurate laboratory diagnoses of these lymphoproliferative diseases and in terms of new comparative prognostic and therapeutic aspects with human diseases.

Prof. Dr. Massimo Vignoli
Dr. Arianna Miglio
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Veterinary Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lymphoma
  • dog
  • cat
  • horse
  • ruminant
  • diagnosis
  • treatment
  • prognosis

Published Papers (1 paper)

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Research

Article
Prognostic Value of PD-L1, PD-1 and CD8A in Canine Diffuse Large B-Cell Lymphoma Detected by RNAscope
Vet. Sci. 2021, 8(7), 120; https://0-doi-org.brum.beds.ac.uk/10.3390/vetsci8070120 - 29 Jun 2021
Viewed by 1685
Abstract
Immune checkpoints are a set of molecules dysregulated in several human and canine cancers and aberrations of the PD-1/PD-L1 axis are often correlated with a worse prognosis. To gain an insight into the role of immune checkpoints in canine diffuse large B-cell lymphoma [...] Read more.
Immune checkpoints are a set of molecules dysregulated in several human and canine cancers and aberrations of the PD-1/PD-L1 axis are often correlated with a worse prognosis. To gain an insight into the role of immune checkpoints in canine diffuse large B-cell lymphoma (cDLBCL), we investigated PD-L1, PD-1 and CD8A expression by RNAscope. Results were correlated with several clinico-pathological features, including treatment, Ki67 index and outcome. A total of 33 dogs treated with chemotherapy (n = 12) or chemoimmunotherapy with APAVAC (n = 21) were included. PD-L1 signal was diffusely distributed among neoplastic cells, whereas PD-1 and CD8A were localized in tumor infiltrating lymphocytes. However, PD-1 mRNA was also retrieved in tumor cells. An association between PD-L1 and PD-1 scores was identified and a higher risk of relapse and lymphoma-related death was found in dogs treated with chemotherapy alone and dogs with higher PD-L1 and PD-1 scores. The correlation between PD-L1 and PD-1 is in line with the mechanism of immune checkpoints in cancers, where neoplastic cells overexpress PD-L1 that, in turn, binds PD-1 receptors in activated TIL. We also found that Ki67 index was significantly increased in dogs with the highest PD-L1 and PD-1 scores, indirectly suggesting a role in promoting tumor proliferation. Finally, even if the biological consequence of PD-1+ tumor cells is unknown, our findings suggest that PD-1 intrinsic expression in cDLBCL might contribute to tumor growth escaping adaptive immunity. Full article
(This article belongs to the Special Issue Lymphoma in Animals)
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