Molecular and Cell Biological Innovations in Veterinary Animal Research

Dear Colleagues,

In 1921, two Canadians—Dr. F. Banting and his student C.H. Best—discovered the hormone insulin from canine pancreatic extracts. Furthermore, they showed that high blood glucose levels returned to within the normal range upon the injection of insulin. Almost 100 years later, animals—dogs in particular—have been evolved from experimental or working animals into intimate family members living in close proximity to their owners. This has resulted in high medical care systems for these animals, especially in the Western world. Moreover, production animals are now housed at far larger farms and at higher densities than ever before. This presents an enormous risk to these animals once a microbiological outbreaks occurs. The realization that some of these outbreaks (e.g., Q-fever, SARS) can directly affect the people working with and/or living adjacent to these animals led to the One Health concept. Etiologies and disease progressions are highly similar between humans and animals, and diseases affect humans, animals, and the environment, and vice versa.

The One Health concept was followed by the One Medicine concept, focusing on the similarities in etiology, molecular biology, disease progression, and treatment modalities for humans and animals. This means that the molecular and cell-biological innovations used in the laboratory setting in experimental animals (C. elegans, zebrafish, and rodent models) to benefit human medicine are crucial and may be applicable to the progress of veterinary science as well. It is anticipated that these technical innovations will lead to breakthroughs in modern biomedicine. In order to appreciate these innovations and to provide veterinarians and translational biomedical researchers with the potential of these technologies to advance their field of interest, this Special Issue is devoted to “Molecular and Cell-Biological Innovations to Advance Veterinary Animal Research”. The authors are invited to describe the innovations and make clear to novices and experienced veterinarian researchers how this can be implemented in clinical practice in the near future.

Dr. L.C. Louis Penning
Guest Editor

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