Special Issue "Flavivirus Immunity"
Deadline for manuscript submissions: 20 December 2021.
Interests: virus; arbovirus; Herpes simplex virus; skin; keratinocyte; innate immunity; antiviral response; antimicrobial peptides; interferon-stimulated genes.
Interests: host-pathogen interactions; emerging viruses; arboviruses; skin; PAMPs, PRRs, innate immunity; antiviral response; antimicrobial peptides; inflammatory response
Interests: microbial pathogenesis; host–pathogen interactions; skin inflammation; innate immunity; cell signaling; cellular microbiology; antimicrobial compounds
Flaviviruses such as Dengue, Zika, Yellow fever, West Nile or Usutu viruses, are emerging pathogens resulting in rising infections throughout the world due to international trade globalization and climate changes. There is to date no antivirals whereas vaccines exist against some of them but display variable efficiency. Interactions between flaviviruses and their hosts are complex and result in induction of different types of immune responses. The fastest, the innate immune response, represents the first line of defense against infection. This response is dependent of cytosolic and transmembranar receptors involved in the recognition of conserved molecular patterns of the microorganisms. The subsequent activation of signaling pathways results in production of many cytokines, chemokines, interferon-stimulated genes and antimicrobial peptides as well as by the implementation of various programs of cell death in order to inhibit viral replication. Then, the adaptive immunity is triggered with both humoral and cell-mediated responses. However, many cellular and molecular aspects of these crucial steps to fight viruses remain largely unknown. This Special Issue aims to provide the reader with an overview of the latest works on immunity against flaviviruses. All original research and review articles that contribute to understand flavivirus pathophysiology and host response, including innate and adaptative immunities, are welcome. Identification of cell sensors and signaling pathways or virus associated molecular patterns, characterization of novel actors of the cell innate immunity as well as the description of their antiviral properties, highlighting the role of immune cells and virus-specific humoral response, and unraveling viral evasion strategies are within the scope of this Special Issue. A better understanding of the defense mechanisms involved in host-virus interactions will undoubtedly allow, in the near future, devising new antiviral strategies through the design of novel therapeutic analogs or original preventive strategies against flaviviruses.
Prof. Nicolas Lévêque
Dr. Magali Garcia
Dr. Charles Bodet
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- innate immunity
- adaptative immunity
- pathogen recognition receptors
- pathogen associated molecular patterns
- signaling pathways
- immune cells