Hepatitis C Pathology
A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Animal Viruses".
Deadline for manuscript submissions: closed (30 November 2012) | Viewed by 141638
Special Issue Editor
2. Centre de Recherche en Cancérologie de Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, 69434 Lyon, France
Interests: viral hepatitis; metabolism; chronic liver disease; liver cancer
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Worldwide approximately 130 million people are thought to be infected with hepatitis C virus (HCV). HCV frequently induces chronic liver disease and on the long term cirrhosis and hepatocellular carcinoma. The major clinical manifestations of chronic hepatitis C comprise steatosis, insulin resistance and type 2 diabetes. Mounting evidence suggests that HCV reprograms it’s host metabolism and modulates immune responses. These alterations contribute to the establishment of a liver microenvironment that is favorable for persistent viral replication, but that is also characterized by increased levels of oxidative stress, altered cytokine patterns and inflammatory responses that can trigger auto-immunity as well as fibrosis and ultimately hepatocarcinogenesis. Unraveling the interactions between HCV and its host and the consequential effects on the liver microenvironment and disease progression is an important task in the field. Understanding these events will help to improve therapy and patient care.
Investigators are invited to contribute original research articles or reviews that help us to understand the molecular pathology of chronic hepatitis C with a particular focus on disease progression in respect to:
- metabolic predisposition and HCV infection
- HCV- induced disturbances of carbohydrate and lipid metabolism
- HCV- induced alterations of the energy and redox systems
- HCV-induced alterations of cytokine signaling
- HCV and autoimmunity
Dr. Birke Bartosch
Guest Editor