Special Issue "Hepatocarcinogenesis by Hepatitis C Virus"
Deadline for manuscript submissions: 31 March 2022.
Interests: HCV; HBV; viral hepatitis; hepatocarcinogenesis; NAFLD; NASH; COVID-19; HIV
Special Issues and Collections in MDPI journals
It is well-known that the main cause of hepatocellular carcinoma (HCC) is hepatitis C virus (HCV) infection. Owing to the development of direct acting antivirals, nowadays almost all of HCV-infected patients have been able to eradicate HCV. However, even those patients who achieved a sustained viral response (SVR), especially those with advanced hepatic fibrosis, have developed HCC; therefore, a strategy to prevent HCC is urgently needed. For this aim, the mechanism of hepatocarcinogenesis by HCV, even after the eradication of the virus, should be completely elucidated. According to the studies using transgenic mice, it is demonstrated that mitochondrial dysfunction and subsequent oxidative stress should contribute to the development of HCC. In addition, there are some studies showing that the epigenetic modification by HCV may be associated with hepatocarcinogenesis.
The aim of this Special Issue is to elucidate the molecular mechanism of hepatocarcinogenesis by HCV. Reviews and original research manuscripts with new insights on this topic will be considered.
Dr. Takeya Tsutsumi
Manuscript Submission Information
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- mitochondrial dysfunction
- oxidative stress
- hepatic steatosis
- epigenomic modification