Special Issue "Hepatocarcinogenesis by Hepatitis C Virus"

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Human Virology and Viral Diseases".

Deadline for manuscript submissions: 31 March 2022.

Special Issue Editor

Dr. Takeya Tsutsumi
E-Mail Website
Guest Editor
Division of Infectious Diseases, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
Interests: HCV; HBV; viral hepatitis; hepatocarcinogenesis; NAFLD; NASH; COVID-19; HIV
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

It is well-known that the main cause of hepatocellular carcinoma (HCC) is hepatitis C virus (HCV) infection. Owing to the development of direct acting antivirals, nowadays almost all of HCV-infected patients have been able to eradicate HCV. However, even those patients who achieved a sustained viral response (SVR), especially those with advanced hepatic fibrosis, have developed HCC; therefore, a strategy to prevent HCC is urgently needed. For this aim, the mechanism of hepatocarcinogenesis by HCV, even after the eradication of the virus, should be completely elucidated. According to the studies using transgenic mice, it is demonstrated that mitochondrial dysfunction and subsequent oxidative stress should contribute to the development of HCC. In addition, there are some studies showing that the epigenetic modification by HCV may be associated with hepatocarcinogenesis.

The aim of this Special Issue is to elucidate the molecular mechanism of hepatocarcinogenesis by HCV. Reviews and original research manuscripts with new insights on this topic will be considered.

Dr. Takeya Tsutsumi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • HCV
  • HCC
  • mitochondrial dysfunction
  • oxidative stress
  • hepatic steatosis
  • fibrosis
  • epigenomic modification

Published Papers

This special issue is now open for submission.
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