Special Issue "Retroviral Nucleocapsid Proteins"
Deadline for manuscript submissions: closed (15 October 2021).
Interests: viral nucleocapsids, structural biology
Retroviral nucleocapsid (NC) proteins play a key role in retrovirus replication. These proteins, all equipped with one or two CCHC domains able to bind zinc atoms, are endowed with a strong ability to interact with nucleic acids and to reorganize their structure-classifying NCs as nucleic acid chaperones. A striking feature of these proteins is their involvement in several distinct processes of the replication cycle. Like other viral nucleocapsids, retroviral NCs are characterized by their role in the compaction and protection of viral genomes, as well as in the process of particle assembly. In particular, retroviral NCs have been shown to be critically involved in the selection of RNA molecules that will be packaged in the retroviral particle. In addition to these functions, which, historically, were the first to be known and studied, the protein, in its fully matured form, has been revealed to have a crucial function in reverse transcription (RT) processes, the very specific hallmark of retroviruses. Indeed, NC proteins have been shown to be involved in the initiation of RT, in the strand transfer processes, either the obligatory or internal transfers. Due to their involvement in these processes, NC proteins have a crucial role in the ability of retroviral genomes to rapidly evolve and to bypass immunogenic reactions and antiviral therapies.
In this Special Issue of Viruses we aim for research and review papers that explore the numerous and various aspects of the molecular mechanisms related to the functioning of these pleiotropic proteins.
Dr. Olivier Mauffret
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- selective RNA packaging
- genomic RNA
- reverse transcription
- strand transfers
- chaperon proteins
- disordered proteins
- zinc fingers