Special Issue "Regulatory Mechanisms of Viral UTRs"
Deadline for manuscript submissions: 30 April 2022.
Interests: NMR spectroscopy; isothermal titration calorimetry; differential scanning calorimetry; protein chromatography; X-ray crystallography and molecular dynamics simulations
Viral untranslated regions (UTRs) fold into complex structures to regulate cellular stages of the replication cycles of RNA and related retroviruses. These RNA structural elements are often the most phylogenetically conserved regions of viral genomes. Viral UTRs function as control centers to coordinate a myriad of RNA–RNA, protein–RNA, and small molecule–RNA interactions that confer spatiotemporal regulation on the molecular biology of viral RNA replication. Functions such as viral RNA synthesis, viral protein translation, genome packaging, splicing, innate immunity, and others are regulated through viral UTR interactions. As such, the structures, dynamics, and interaction partners of viral UTRs represent biological systems to better understand molecular virology and targets for therapeutic interventions.
In this Special Issue, we aim to highlight the multifunctional roles of viral UTRs that lead us to posit that they act as regulatory hubs to condition the cell for optimal replication. By looking at viral UTRs through this wider lens, we anticipate that chemical biological strategies can be developed that target specific viral RNA–host interfaces and, as such, pathways.
Prof. Dr. Blanton S. Tolbert
Manuscript Submission Information
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- RNA viruses
- untranslated regions
- noncoding RNAs
- RNA structure
- RNA dynamics
- protein–RNA interactions
- RNA binding proteins
- genome packaging
- innate immunity