Special Issue "Regulatory Mechanisms of Viral UTRs"

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "General Virology".

Deadline for manuscript submissions: 30 April 2022.

Special Issue Editor

Prof. Dr. Blanton S. Tolbert
E-Mail Website
Guest Editor
Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106, USA
Interests: NMR spectroscopy; isothermal titration calorimetry; differential scanning calorimetry; protein chromatography; X-ray crystallography and molecular dynamics simulations

Special Issue Information

Dear Colleagues,

Viral untranslated regions (UTRs) fold into complex structures to regulate cellular stages of the replication cycles of RNA and related retroviruses. These RNA structural elements are often the most phylogenetically conserved regions of viral genomes. Viral UTRs function as control centers to coordinate a myriad of RNA–RNA, protein–RNA, and small molecule–RNA interactions that confer spatiotemporal regulation on the molecular biology of viral RNA replication. Functions such as viral RNA synthesis, viral protein translation, genome packaging, splicing, innate immunity, and others are regulated through viral UTR interactions. As such, the structures, dynamics, and interaction partners of viral UTRs represent biological systems to better understand molecular virology and targets for therapeutic interventions.

In this Special Issue, we aim to highlight the multifunctional roles of viral UTRs that lead us to posit that they act as regulatory hubs to condition the cell for optimal replication. By looking at viral UTRs through this wider lens, we anticipate that chemical biological strategies can be developed that target specific viral RNA–host interfaces and, as such, pathways.

Prof. Dr. Blanton S. Tolbert
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • RNA viruses
  • retroviruses
  • untranslated regions
  • noncoding RNAs
  • RNA structure
  • RNA dynamics
  • protein–RNA interactions
  • IRES
  • RNA binding proteins
  • genome packaging
  • splicing
  • innate immunity

Published Papers

This special issue is now open for submission.
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