Special Issue "Cell-Host Interplay for Viral Nuclear Import"
Deadline for manuscript submissions: closed (30 September 2021).
Access to the nuclear environment offers numerous benefits for viral replication and persistence. During viral infection, self-defense mechanisms are activated in the host cells to survive in response to viral invasion. Many of these mechanisms interfere with the viral journey towards the nucleus. However, viruses have evolved divergent strategies to evade an antiviral innate immunity response and to penetrate the nuclear compartment to deliver their genome. Most of them hijack the nuclear pore complex (NPC) of post-mitotic cells to reach the host nuclear environment. Usually, the nuclear entry step represents the bottleneck for the replication of many viruses due to the large size of their capsid. To counteract this steric obstacle, viruses evolved intriguing and fascinating strategies to cross the NPC to reach the host nucleus to generate new progeny. Those viruses establish an interplay between their own proteins and host factors to control the outcome of infection. Increasing the understanding of these processes will trigger the design of new drug strategies to tackle host–pathogen interactions for viral cures. Of note, in recent years, cutting-edge technologies have begun to shed light on the mechanisms underlying the viral nuclear entry. This Special Issue will overview mechanisms of nuclear import developed by viruses to invade the host.
Dr. Francesca Di Nunzio
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- nuclear import
- host-viral interactions
- nuclear pore and nuclear dynamics