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Vision
Special Issues
Ocular Blood Flow and Visual Function
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Ocular Blood Flow and Visual Function

A special issue of Vision (ISSN 2411-5150).

Deadline for manuscript submissions: closed (31 March 2021) | Viewed by 5823

Special Issue Editor

Dr. Tetsuya Sugiyama

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Guest Editor
Department of Ophthalmology, Osaka Medical College, 2-7, Daigaku-machi, Takatsuki, Osaka 569-8686, Japan
Interests: glaucoma; ocular blood flow; ocular pharmacology; P2X7 receptor
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Ocular blood flow (OBF) and its regulation are obviously crucial for visual function; its disturbance induces various ocular diseases. The autoregulation of OBF functions as a physiological response to postural changes and intraocular pressure changes. OBF measurement techniques have been developed in recent years with the introduction of several new techniques. Particularly, optical coherence tomography angiography and laser speckle flowgraphy are both noninvasive imaging devices that detect OBF through the motion contrast generated by red blood cells.

This Special Issue focuses on the relationship between OBF and visual function in physiological or pathological conditions. For example, research regarding the impact of OBF disturbances on the progression of glaucoma or other ocular diseases would be welcome.

Dr. Tetsuya Sugiyama
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vision is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ocular blood flow
  • optical coherence tomography angiography
  • laser speckle flowgraphy
  • autoregulation
  • glaucoma
  • age-related macular degeneration
  • ischemic optic neuropathy

Published Papers (2 papers)

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Research

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17 pages, 2190 KiB  
Article
The Effect of Ocular Perfusion Pressure on Retinal Thickness in Young People with Presumed Systemic Hypotension
by Naazia Vawda and Alvin Munsamy
Vision 2021, 5(3), 36; https://0-doi-org.brum.beds.ac.uk/10.3390/vision5030036 - 14 Jul 2021
Viewed by 2537
Abstract
Low ocular perfusion pressure (OPP) may increase the risk of optic neuropathy. This study investigated the effects of OPP on the ganglion cell complex (GCC) and optic nerve head-retinal nerve fibre layer (ONH-RNFL) thickness in presumed systemic hypotensives (PSH). Fifteen participants with PSH [...] Read more.
Low ocular perfusion pressure (OPP) may increase the risk of optic neuropathy. This study investigated the effects of OPP on the ganglion cell complex (GCC) and optic nerve head-retinal nerve fibre layer (ONH-RNFL) thickness in presumed systemic hypotensives (PSH). Fifteen participants with PSH and 14 controls underwent automated sphygmomanometry and Icare tonometry to calculate OPP: mean OPP (MOPP), systolic OPP (SOPP), and diastolic OPP (DOPP). ONH-RNFL and macula GCC thickness were evaluated using the Optovue iVue optical coherence tomographer. Statistical analysis comprised independent t-tests, the Mann–Whitney U test and binary logistic regression analysis. There was no significant difference when comparing ONH-RNFL and macula GCC thickness between both groups. Increased MOPP (OR = 0.51; 95% CI: 0.27–0.97; p = 0.039) and SOPP (OR = 0.79; 95% CI: 0.64–0.98; p = 0.035) were significantly associated with a decreased risk of reductions in GCC total thickness. Increased SOPP (OR = 0.11; 95% CI: 0.01–0.89; p = 0.027) was significantly associated with a decreased risk of reductions in the average ONH-RNFL thickness. The study found no significant retinal thickness changes in PSH’s, in comparison to the controls. The study established that, by increasing MOPP and SOPP, there was a decreased risk of reductions in the total GCC thickness and average ONH-RNFL thickness. Higher SOPP may decrease the possibility of retinal thinning of the GCC and ONH-RNFL. However, higher MOPP may decrease the odds of thinning of the GCC before ONH-RNFL changes. Full article
(This article belongs to the Special Issue Ocular Blood Flow and Visual Function)
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10 pages, 7779 KiB  
Case Report
Time Course in Ocular Blood Flow and Pulse Waveform in a Case of Ocular Ischemic Syndrome with Intraocular Pressure Fluctuation
by Ryo Yamazaki, Ryuya Hashimoto, Hidetaka Masahara, Masashi Sakamoto and Takatoshi Maeno
Vision 2020, 4(2), 31; https://0-doi-org.brum.beds.ac.uk/10.3390/vision4020031 - 10 Jun 2020
Cited by 2 | Viewed by 2668
Abstract
We report on a 70-year-old Japanese man with complaints of worsening left visual acuity who was diagnosed with ocular ischemic syndrome (OIS) associated with internal carotid artery (ICA) stenosis. A gonioscopy examination showed rubeosis iridis and elevated intraocular pressure (IOP) in the left [...] Read more.
We report on a 70-year-old Japanese man with complaints of worsening left visual acuity who was diagnosed with ocular ischemic syndrome (OIS) associated with internal carotid artery (ICA) stenosis. A gonioscopy examination showed rubeosis iridis and elevated intraocular pressure (IOP) in the left eye (50 mmHg) at the baseline visit. The optic nerve head (ONH) and choroidal blood flow measured by laser speckle flowgraphy (LSFG) was impaired in the left eye compared with that in the right eye. Additionally, the blowout score (BOS), which indicates the variation of the mean blur rate (MBR) during systolic and diastolic periods, was decreased in the left eye. After treatment with an injection of bevacizumab and administration of Rho-associated kinase-inhibitor ripasudil eye drops, both ocular blood flow and BOS in each vascular bed gradually increased along with IOP reduction. The visual acuity also improved. The current case demonstrated increased blood flow and decreased fluctuation of blood flow in the ONH and choroid before and after the treatment in OIS with rubeosis iridis. The LSFG technique is useful to non-invasively assess the ocular circulation and pulse waveform in OIS. Full article
(This article belongs to the Special Issue Ocular Blood Flow and Visual Function)
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