Metal Coordination Complexes in Biological Systems

Topic Information

Dear Colleagues,

Metal complexes and inorganic salts are used for medicinal purposes since ancient times. Antimony was used by Assyrians for urinary tract afflictions. Antimony compounds were used in Europe from the Middle Ages until the nineteenth century as laxatives and “humor cleansers.” Today, antimony salts are employed against schistosomiasis and leishmaniasis. Other metal compounds currently used in medicine include gold(I) complexes such as aurothiomalate (Myocrisin), aurothioglucose (Solganol), aurothiopropanol sulfonate (Allochrysin), and the oral drug auranofin (Ridaura) for the treatment of difficult cases of rheumatoid arthritis (37), bismuth subcitrate, and subsalicylate are for the treatment of diarrhea, dyspepsia and gastric ulcers, and the world-famous cisplatin for cancer chemotherapy.

Metal complexes are less abundant medicines than the purely organic small molecules, mainly due to the difficulty in establishing high-throughput screening and synthesis methods for their preparation and evaluation, in addition to the higher cost of production of molecules incorporating one or more metal atoms. Nevertheless, metal complexes have been continuously and increasingly investigated as promising sources of innovative drugs for challenging pathologies such as cancer, metabolic diseases, microbial infection, and neglected tropical diseases.

The topic “Metal Coordination Complexes in Medicine” welcomes contributions that describe interesting advances in the field or identify new targets for metals in biological systems. The submitted papers can encompass both research articles and critical reviews, the latter of which is expected to direct readers to new avenues of research in metal drug development.

Dr. Susana Santos Braga
Dr. Filipe Alexandre Almeida Paz
Topic Editors

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Participating Journals

Journal Name	Impact Factor	CiteScore	Launched Year	First Decision (median)	APC
Applied Sciences applsci	2.7	4.5	2011	16.9 Days	CHF 2400
Bioengineering bioengineering	4.6	4.2	2014	17.7 Days	CHF 2700

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19 pages, 24619 KiB  

Open AccessArticle

Synthesis, Spectroscopic Characterization and Biological Studies of Mn(II), Cu(II), Ni(II), Co(II) and Zn(II) Complexes with New Schiff Base of 2-((Pyrazine-2-ylimino)methyl)phenol

by Hanan B. Howsaui, Abeer A. Sharfalddin, Magda H. Abdellattif, Amal S. Basaleh and Mostafa A. Hussien

Appl. Sci. 2021, 11(19), 9067; https://0-doi-org.brum.beds.ac.uk/10.3390/app11199067 - 29 Sep 2021

Cited by 16 | Viewed by 3361

Abstract

In the search for novel anticancer complex, transition metal complexes of Schiff base derived from 2-aminopyrazine and salicylaldehyde were successfully synthesized and characterized based on elemental analyses, spectroscopic and thermal analysis. The IR spectra showed the ligand is a tridentate chelator with O, [...] Read more.

In the search for novel anticancer complex, transition metal complexes of Schiff base derived from 2-aminopyrazine and salicylaldehyde were successfully synthesized and characterized based on elemental analyses, spectroscopic and thermal analysis. The IR spectra showed the ligand is a tridentate chelator with O, N and N atoms. donor sites in the Zn(II), Co(II), Ni(II), and Mn(II) complexes. Contrary, it behaved a bidentate chelator in the Cu complex by O and N. Molar ratio data revealed that the ligand to metal ratio was 1:2 for Co(II) Cu(II) and Zn(II) while it was 1:1 for Mn(II) and Ni(II) complexes. The obtained complexes have the formulae [M(L)₂] (where M = Co(II) and Zn(II), [M(L)Cl(2H₂O)]·H₂O (where M = Ni(II) and Mn(II) were octahedral geometry). The computational studies were performed by DFT calculations to compare the optimized geometries with the experimental values. The interaction of these complexes with calf thymus DNA (CT-DNA) was investigated by UV-Vis spectroscopic technique. Molecular docking studies were against three protein cancer to investigate the binding ability of the new compounds. The anticancer activity was studied with different cell lines and the IC₅₀ of the Cu(II) complex for (HOP-62) showed a practical result. The LD₅₀ values of Zn(II) and Co(II) complexes showed that they are non-toxic at doses up to 370 mg/kg. Full article

(This article belongs to the Topic Metal Coordination Complexes in Biological Systems)

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