5-Chloro-8-{[1-(2-chlorobenzyl)-1H-1,2,3-triazol-4-yl]methoxy}quinoline
Round 1
Reviewer 1 Report
In this paper the authors described the convergent synthesis of a hybrid heterocycle obtained by clicking a substituted propargyl quinoline with an aromatic azide. The molecule is novel and the spectroscopic techniques performed for its structural elucidation are convincing. The manuscript fits the Molbank's publication criteria but english editing as well as a greater care in the description of the experimental procedures are strongly recommended. In addition, the authors should specify that the molecular ion is a radical cation in the experimental section.
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Reviewer 2 Report
This paper describes enough simple synthesis of the triazolyl derivative of 8-oxyquinoline accomplihse via 3 steps which are quite well known for every organic chemist. The significance of the synthesis of this compound can be improved if the authors provide more details about the choice of the substituents (Cl in position 4 of quinoline and 2 of benzyl). Also it should be mentioned what other classes of N-substituted triazolyl derivatives of quinoline have benn already obtained. Otherwise it is difficult to judge the novelty of this work.
Possible corrections:
1) the expression "quinoline hybrid molecule" is not appropriate, it is better to use "quinoline derivative"
2) Why compound 4 is given in the brackets? It is not an intermediate, simply it was used without purification, even not in situ.
3) When describing proton NMR it is better to indicate the same coupling constants for two protons in corresponding multiplets. I am aware of the problem that in heteroaromatics different protons display multiplets with different line broadening and the fact of different observed J(HH) arises from this feature. Howevere, in the case of this molecule the difference is indeed negilgible (8.4-8.6 Hz).
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