5-Ethoxy-1-(4-methoxyphenyl)-5-methyl-3-phenylimidazolidine-2,4-dione
, Adrián López-Francés, Edorta Martinez de Marigorta, Francisco Palacios * and Javier Vicario *Round 1
Reviewer 1 Report
This manuscript deals with synthesis of new hydantoin derivative, which is a novel piece of heterocyclic chemistry. I think it is acceptable for publication in Molbank, however, several issues should be addressed before it.
1) From page 2 to 3, each signals of 1H and 13C NMR spectra and absorptions are assigned. However, readers of this journal are specialists in organic chemistry. So, it is not necessary to explain as that for students. Authors should indicate key spectral data for the determination of the title compound.
2) The assignment of an ethoxy methylene is described as double triplet. I think it is incorrect. The two hydrogens should appear as a double quartet. In addition, the methyl group should be assigned as double doublet even though it looks like a triplet.
Author Response
1) From page 2 to 3, each signals of 1H and 13C NMR spectra and absorptions are assigned. However, readers of this journal are specialists in organic chemistry. So, it is not necessary to explain as that for students. Authors should indicate key spectral data for the determination of the title compound.
1H and 13C NMR and IR descriptions have been summarized.
2) The assignment of an ethoxy methylene is described as double triplet. I think it is incorrect. The two hydrogens should appear as a double quartet. In addition, the methyl group should be assigned as double doublet even though it looks like a triplet.
The two diatereotopic protons of ethoxy methylene group are now described as double quartets and the methyl group is now a double doublet with equal coupling constants.
Reviewer 2 Report
The submitted manuscript is of a very high quality and surely fulfills all of the requirements. The Authors present an efficient method of synthesis of a new compound with potential biological activity. This is also supported with the proper structural analysis by the means of NMR and FT-IR spectroscopic methods and, what is important, a SCXRD structure. My comments are minor ones.
1.Lines 65-78, the 13C NMR chemical shift assignment could be presented in a form of a Table to increase the clarity.
Line 95, it should be “X-ray”
Figure 2, it should be “X-ray”, besides it would be nice to present the crystal arrangement with intermolecular interactions, if there are any (maybe CH3-π ?)
Also, a table summarizing the crystal structure properties (unit cell dimensions, space group, etc.) could be introduced.
Line 128, it should me “NMR” not “RMN”
Line 169, “X-ray”
Author Response
The submitted manuscript is of a very high quality and surely fulfills all of the requirements. The Authors present an efficient method of synthesis of a new compound with potential biological activity. This is also supported with the proper structural analysis by the means of NMR and FT-IR spectroscopic methods and, what is important, a SCXRD structure. My comments are minor ones.
1) Lines 65-78, the 13C NMR chemical shift assignment could be presented in a form of a Table to increase the clarity.
Following the suggestions from referee Nr 1 we have summarized the NMR description. The text is now not so extensive and, therefore a table is not needed after the modification. A list of peaks is, however presented in the experimental.
2) Line 95, it should be “X-ray”
Corrected
3) Figure 2, it should be “X-ray”, besides it would be nice to present the crystal arrangement with intermolecular interactions, if there are any (maybe CH3-π ?)
Figure 2 Corrected. We have checked the crystal arrangement together with the general X-ray service of our university and there does not seem to be any clear intermolecular interaction
4) Also, a table summarizing the crystal structure properties (unit cell dimensions, space group, etc.) could be introduced.
A table with structure properties has been introduced in ESI
5) Line 128, it should me “NMR” not “RMN”
Corrected
6) Line 169, “X-ray”
Corrected
Round 2
Reviewer 1 Report
The manuscript has been revised according to the comments. So, I think it is acceptable for publication in Molbank.
