Naphthalen-2-yl 1-(benzamido(diethoxyphosphoryl)methyl)-1H-1,2,3-triazole-4-carboxylate
, Mohamed Akhazzane 1,3, Brahim Labriti 1, Hassane Faraj 1 and Anouar Alami 1,*Round 1
Reviewer 1 Report
Alami and coworkers described the preparation of Naphthalen-2-yl-1-(benzamido(diethoxyphosphoryl)-2-methyl)-1H-1,2,3-triazole-4-carboxylate via copper-catalyze [3+2] cycloaddition of diethyl (α-azido(benzamido)methyl)phosphonate and 2-naphthyl propiolate. The compound was well-characterized via 1H, 13C and 31P NMR spectroscopies as well as 2D NMR spectroscopies. The work was solid and well-done and the manuscript was well-written. I suggest to accept it as it is.
Author Response
Dear reviewer
All the authors thank you for the time you took to evaluate our research work.
We have made some minor modifications in order to improve the quality of our paper.
Best regards
Prof. Anouar Alami
Reviewer 2 Report
This contribution reports the synthesis of an interesting new phosponic aminoester 1,2,3-triazole compound. This compound has some potential for anticorrosion and biological applications.
The synthetic method is appropriate as well as convenient. The [3+2] dipolar cycloaddition between an azide and the commercially available alkyne (click chemistry) is one of the best methods to regioselectively obtain the 1,4-isomer of 1,2,3-triazole rings in excellent yields while minimizing waste.
Therefore, this manuscript provides a useful synthetic approach that can be easily used to prepare the named compound.
NMR spectroscopy (1H, 13C, and 31P) has adequately identified and quantified the compound to a high standard. The authors also provide complete NMR assignments (both 1H and 13C) using COSY and HSQC, which is also adequate.
In addition, IR and HRMS characterization has been carried out.
The introduction is well structured and nicely written, easy to follow for a wider audience. It also provided the present work in the proper context.
Experimental synthetic work has been carefully carried out at high technical standards, reported, and accurately interpreted.
With all of this in mind, the present work's degree of novelty and quality could warrant publication in Molbank.
The authors should consider one minor additional comment:
- What type of 1H decoupled 13C NMR has the authors used in Figure 3? I would suggest adding this little extra information (APT, DEPT-125, ?) to Figure 3 and where appropriate.
Author Response
Dear reviewer
All the authors thank you for the time you took to evaluate our research work.
Please find attached the revised paper. You will find below the answers to your comments and suggestions, point by point.
- What type of 1H decoupled 13C NMR has the authors used in Figure 3?
The technique adopted in 13C NMR is the J-mod variant; because it shows a phase distinction between CH3 and CH on the one hand (the odd ones) and CH2 and quaternary carbons on the other hand (the pairs).
- I would suggest adding this little extra information (APT, DEPT-125, ?) to Figure 3 and where appropriate.
Suggestion done
Best regards
Prof. Anouar Alami
Author Response File: 
Author Response.pdf
