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Case Report

What the Cardiologist Needs to Consider in the Management of Oncologic Patients with STEMI-Like Syndrome: A Case Report and Literature Review

1
Cardiothoracovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), 34149 Trieste, Italy
2
Department of Medical Surgical and Health Science, University of Trieste, 34149 Trieste, Italy
3
Department of Perioperative Medicine, Intensive Care and Emergency, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), 34149 Trieste, Italy
4
Oncology Department, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), 34149 Trieste, Italy
5
Department of Medicine (DAME), University of Udine, 33100 Udine, Italy
*
Author to whom correspondence should be addressed.
Academic Editors: Anton G. Kutikhin and Serge Mordon
Pharmaceuticals 2021, 14(6), 563; https://0-doi-org.brum.beds.ac.uk/10.3390/ph14060563
Received: 7 May 2021 / Revised: 3 June 2021 / Accepted: 8 June 2021 / Published: 12 June 2021
In pre-hospital care, an accurate and quick diagnosis of ST-segment elevation myocardial infarction (STEMI) is imperative to promptly kick-off the STEMI network with a direct transfer to the cardiac catheterization laboratory (cath lab) in order to reduce myocardial infarction size and mortality. Aa atherosclerotic plaque rupture is the main mechanism responsible for STEMI. However, in a small percentage of patients, emergency coronarography does not reveal any significant coronary stenosis. The fluoropyrimidine agents such as 5-Fluorouracil (5-FU) and capecitabine, widely used to treat gastrointestinal, breast, head and neck cancers, either as a single agent or in combination with other chemotherapies, can cause potentially lethal cardiac side effects. Here, we present the case of a patient with 5-FU cardiotoxicity resulting in an acute coronary syndrome (ACS) with recurrent episodes of chest pain and ST-segment elevation.. Our case report highlights the importance of widening the knowledge among cardiologists of the side effects of chemotherapeutic drugs, especially considering the rising number of cancer patients around the world and that fluoropyrimidines are the main treatment for many types of cancer, both in adjuvant and advanced settings. View Full-Text
Keywords: 5-Fluorouracil; acute myocardial infarction; acute coronary syndrome; ST-segment elevation myocardial infarction—STEMI; coronary spasm; myocardial enzymes; troponin I; chest pain; cardiotoxicity 5-Fluorouracil; acute myocardial infarction; acute coronary syndrome; ST-segment elevation myocardial infarction—STEMI; coronary spasm; myocardial enzymes; troponin I; chest pain; cardiotoxicity
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MDPI and ACS Style

Aleksova, A.; Gagno, G.; Pierri, A.; Todaro, C.; Fluca, A.L.; Orlando, V.; Guglielmi, A.; Beltrami, A.P.; Sinagra, G. What the Cardiologist Needs to Consider in the Management of Oncologic Patients with STEMI-Like Syndrome: A Case Report and Literature Review. Pharmaceuticals 2021, 14, 563. https://0-doi-org.brum.beds.ac.uk/10.3390/ph14060563

AMA Style

Aleksova A, Gagno G, Pierri A, Todaro C, Fluca AL, Orlando V, Guglielmi A, Beltrami AP, Sinagra G. What the Cardiologist Needs to Consider in the Management of Oncologic Patients with STEMI-Like Syndrome: A Case Report and Literature Review. Pharmaceuticals. 2021; 14(6):563. https://0-doi-org.brum.beds.ac.uk/10.3390/ph14060563

Chicago/Turabian Style

Aleksova, Aneta, Giulia Gagno, Alessandro Pierri, Carla Todaro, Alessandra L. Fluca, Valentina Orlando, Alessandra Guglielmi, Antonio P. Beltrami, and Gianfranco Sinagra. 2021. "What the Cardiologist Needs to Consider in the Management of Oncologic Patients with STEMI-Like Syndrome: A Case Report and Literature Review" Pharmaceuticals 14, no. 6: 563. https://0-doi-org.brum.beds.ac.uk/10.3390/ph14060563

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