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Article

Role of Periodontal Bacteria, Viruses, and Placental mir155 in Chronic Periodontitis and Preeclampsia—A Genetic Microbiological Study

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Department of Periodontology, Meenakshi Ammal Dental College and Hospital, Chennai 600095, India
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Department of Periodontology, Maktoum Bin Hamdan Dental University College, Dubai 213620, United Arab Emirates
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Department of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University, Jazan 45412, Saudi Arabia
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Department of Prosthetic Dental Sciences, College of Dentistry, Jazan University, Jazan 45412, Saudi Arabia
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Department of Restorative Dental Sciences, College of Dentistry, Jazan University, Jazan 45412, Saudi Arabia
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College of Dentistry, Jazan University, Jazan 45412, Saudi Arabia
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Tagore Dental College and Hospital, Chennai 600127, India
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Department of Oral Pathology and Microbiology, Sri Venkateswara Dental College and Hospital, Chennai 600130, India
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Department of Periodontics, Narayana Dental College and Hospital, Nellore 534003, Andhra Pradesh, India
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Department of Oral and Maxillo Facial Sciences, University of Rome La Sapienza, 00161 Rome, Italy
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Division of Oral Pathology, Department of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University, Jazan 45412, Saudi Arabia
*
Authors to whom correspondence should be addressed.
Academic Editor: Arumugam R. Jayakumar
Curr. Issues Mol. Biol. 2021, 43(2), 831-844; https://0-doi-org.brum.beds.ac.uk/10.3390/cimb43020060
Received: 29 June 2021 / Revised: 21 July 2021 / Accepted: 22 July 2021 / Published: 29 July 2021
(This article belongs to the Special Issue Advance Research on Molecular Oral Microorganism)
Previous studies assessed the involvement and impact of periodontal bacteria in preeclamptic women with chronic periodontitis. To explore further, the current study aimed to associate periodontal viruses and bacteria with mir155 levels in placental tissues of preeclamptic women with generalized chronic periodontitis. Four-hundred 45 pregnant women, 18–35 years of age, were selected and divided into four groups (controls, A, B, and C) where the Controls included 145 systemically and periodontally healthy pregnant women Group A-100 systemically healthy pregnant women with chronic periodontitis, Group B- 100 preeclamptic women with chronic periodontitis, Group C- 100 preeclamptic women without chronic periodontitis. Age, BMI, SES, and periodontal parameters such as PI, BOP, PPD, and CAL were noted. Periodontal pathogens such as Tf, Td, Pg, Pi, Fn, HSV, EBV, and HCMV were tested in subgingival plaque, placental tissues, and mir155. We observed that PI, BOP, PPD, CAL, Tf, and EBV were highly significant in Group B. We found a higher number of periodontal bacteria, viruses, and mir 155 in Group B showing a higher risk of preeclampsia. More genetic studies in this field are advised to ascertain the role of periodontopathogens and mir 155 in preeclampsia and periodontal inflammation. What is already known on this subject? Periodontal diseases pose an increased risk of developing preeclampsia and delivering preterm and/or low-birth-weight babies. What do the results of this study add? Periodontal variables such as PI, pocket depth, BOP, and clinical attachment levels, were found to be increased in the preeclamptic women with chronic periodontitis. The significant difference was seen in the relative fold expression of mir155 with higher gene expression of mir155 in groups B and A as compared to group C and controls. What are the implications of these findings for clinical practice and/or further research? In our study, mir155 correlation with the periodontal parameters and periodontal pathogens further strengthen the evidence of periodontal inflammation as a risk of preeclampsia in pregnant women especially when associated with chronic periodontitis. mir155 can be considered to be one of the genetic biomarkers and can be used as a diagnostic tool for the early detection of PE. View Full-Text
Keywords: chronic periodontitis; mir 155; periodontal microflora; preeclampsia; pregnancy chronic periodontitis; mir 155; periodontal microflora; preeclampsia; pregnancy
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MDPI and ACS Style

Mahendra, J.; Mahendra, L.; Mugri, M.H.; Sayed, M.E.; Bhandi, S.; Alshahrani, R.T.; Balaji, T.M.; Varadarajan, S.; Tanneeru, S.; P., A.N.R.; Srinivasan, S.; Reda, R.; Testarelli, L.; Patil, S. Role of Periodontal Bacteria, Viruses, and Placental mir155 in Chronic Periodontitis and Preeclampsia—A Genetic Microbiological Study. Curr. Issues Mol. Biol. 2021, 43, 831-844. https://0-doi-org.brum.beds.ac.uk/10.3390/cimb43020060

AMA Style

Mahendra J, Mahendra L, Mugri MH, Sayed ME, Bhandi S, Alshahrani RT, Balaji TM, Varadarajan S, Tanneeru S, P. ANR, Srinivasan S, Reda R, Testarelli L, Patil S. Role of Periodontal Bacteria, Viruses, and Placental mir155 in Chronic Periodontitis and Preeclampsia—A Genetic Microbiological Study. Current Issues in Molecular Biology. 2021; 43(2):831-844. https://0-doi-org.brum.beds.ac.uk/10.3390/cimb43020060

Chicago/Turabian Style

Mahendra, Jaideep, Little Mahendra, Maryam H. Mugri, Mohammed E. Sayed, Shilpa Bhandi, Rahaf T. Alshahrani, Thodur M. Balaji, Saranya Varadarajan, Swetha Tanneeru, Abirami N.R. P., Sruthi Srinivasan, Rodolfo Reda, Luca Testarelli, and Shankargouda Patil. 2021. "Role of Periodontal Bacteria, Viruses, and Placental mir155 in Chronic Periodontitis and Preeclampsia—A Genetic Microbiological Study" Current Issues in Molecular Biology 43, no. 2: 831-844. https://0-doi-org.brum.beds.ac.uk/10.3390/cimb43020060

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