Cell proliferation and apoptosis in Wistar rat kidney after renal mass ablation and low-dose irradiation
1
Department of Anatomy, University of Tartu, Estonia
2
Department of Morphology, Estonian University of Life Sciences, Tartu
3
Department of Internal Medicine, University of Tartu, Estonia
4
Institute of Anthropology and Anatomy, Riga Stradins University, Latvia
*
Author to whom correspondence should be addressed.
Medicina 2010, 46(3), 204; https://0-doi-org.brum.beds.ac.uk/10.3390/medicina46030029
Submission received: 17 March 2009
/
Accepted: 5 March 2010
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Published: 10 March 2010
Abstract
Cell proliferation and apoptosis in the remnant rat kidney after treatment with lowdose irradiation was investigated.
Material and methods. In the first group (n=9), adult male Wistar rats underwent 5/6 nephrectomy (NPX); in the second group (n=9), NPX was combined with low-dose irradiation. Rats without surgery and irradiation formed the control group (n=9).
Results. Hypertension and proteinuria induced by NPX were decreased by 3-Gy irradiation. The 5/6 NPX rats showed a dramatic increase in proliferating and apoptotic cells in the glomeruli and in the distal tubules at week 2, which was significantly decreased by low-dose irradiation.
Conclusion. The data demonstrate that low-dose irradiation is a factor slowing the process of chronic renal injury.
Material and methods. In the first group (n=9), adult male Wistar rats underwent 5/6 nephrectomy (NPX); in the second group (n=9), NPX was combined with low-dose irradiation. Rats without surgery and irradiation formed the control group (n=9).
Results. Hypertension and proteinuria induced by NPX were decreased by 3-Gy irradiation. The 5/6 NPX rats showed a dramatic increase in proliferating and apoptotic cells in the glomeruli and in the distal tubules at week 2, which was significantly decreased by low-dose irradiation.
Conclusion. The data demonstrate that low-dose irradiation is a factor slowing the process of chronic renal injury.
Keywords:
remnant kidney; rat; low-dose radiation; cell proliferation; apoptosis
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MDPI and ACS Style
Aunapuu, M.; Arend, A.; Ots, M.; Pilmane, M. Cell proliferation and apoptosis in Wistar rat kidney after renal mass ablation and low-dose irradiation. Medicina 2010, 46, 204. https://0-doi-org.brum.beds.ac.uk/10.3390/medicina46030029
AMA Style
Aunapuu M, Arend A, Ots M, Pilmane M. Cell proliferation and apoptosis in Wistar rat kidney after renal mass ablation and low-dose irradiation. Medicina. 2010; 46(3):204. https://0-doi-org.brum.beds.ac.uk/10.3390/medicina46030029
Chicago/Turabian StyleAunapuu, Marina, Andres Arend, Mai Ots, and Mara Pilmane. 2010. "Cell proliferation and apoptosis in Wistar rat kidney after renal mass ablation and low-dose irradiation" Medicina 46, no. 3: 204. https://0-doi-org.brum.beds.ac.uk/10.3390/medicina46030029
