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Case Report

Pediatric Thioridazine Poisoning as a Result of Pharmacy Compounding Error

by
Zenichiro Kato
1,2,3,4,*,
Mitsuhiro Nakamura
5,
Yuka Yamagishi
1,
Takahide Teramoto
1 and
Naomi Kondo
1,2,3
1
Department of Pediatrics, Graduate School of Medicine, Japan
2
Center for Emerging Infectious Diseases, Japan
3
Center for Advanced Drug Research, Gifu University, Gifu, Japan
4
Molecular Cellular Biology, Harvard University, Cambridge MA, USA
5
Laboratory of Drug Informatics, Gifu Pharmaceutical University, Gifu, Japan
*
Author to whom correspondence should be addressed.
Submission received: 20 June 2009 / Revised: 20 June 2009 / Accepted: 9 November 2009 / Published: 23 December 2009

Abstract

The adverse effects or overdose of thioridazine including sudden death, fatal arrhythmia, or retinopathy, in addition to the neurological signs have been reported. A three-year-old boy with bronchitis was prescribed erythromycin by a local clinic, but he started to complain of severe drowsiness and became unconscious. It was decided that this was a result of a compounding error of thioridazine instead of erythromycin owing to their similar commercial names. The thioridazine concentration in the child’s serum on admission was two to three times higher than the Cmax for adults with the same dosage. The concentration of the lavage saline on admission was only 0.3% of the ingested amount, indicating that the lavage was not effective in our case. Pharmacokinetic analysis revealed the parameters as Tmax, 1.5 hr; Cmax, 1700 ng/mL; Ka, 2.01 L/hr; Vd, 3.6 L/kg; and T1/2, 6.8 hr. Further investigations on clinical cases with a pharmacokinetic analysis should be done to confirm the pharmacokinetic evidence obtained here and to give specific therapeutic guidelines for overdose management especially in children.
Keywords: Thioridazine; compounding error; pharmacokinetics Thioridazine; compounding error; pharmacokinetics

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MDPI and ACS Style

Kato, Z.; Nakamura, M.; Yamagishi, Y.; Teramoto, T.; Kondo, N. Pediatric Thioridazine Poisoning as a Result of Pharmacy Compounding Error. Pediatr. Rep. 2009, 1, e9. https://0-doi-org.brum.beds.ac.uk/10.4081/pr.2009.e9

AMA Style

Kato Z, Nakamura M, Yamagishi Y, Teramoto T, Kondo N. Pediatric Thioridazine Poisoning as a Result of Pharmacy Compounding Error. Pediatric Reports. 2009; 1(1):e9. https://0-doi-org.brum.beds.ac.uk/10.4081/pr.2009.e9

Chicago/Turabian Style

Kato, Zenichiro, Mitsuhiro Nakamura, Yuka Yamagishi, Takahide Teramoto, and Naomi Kondo. 2009. "Pediatric Thioridazine Poisoning as a Result of Pharmacy Compounding Error" Pediatric Reports 1, no. 1: e9. https://0-doi-org.brum.beds.ac.uk/10.4081/pr.2009.e9

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