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Case Report

Acquired Zinc Deficiency Mimicking Acrodermatitis Enteropathica in a Breast-Fed Premature Infant

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Department of Pediatrics, Hôpital Universitaire des Enfants Reine Fabiola, Université Libre de Bruxelles, Avenue Jean Joseph Crocq 15, 1020 Brussels, Belgium
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Nutrition and Metabolic Unit, Hôpital Universitaire des Enfants Reine Fabiola, Université Libre de Bruxelles, Avenue Jean Joseph Crocq 15, 1020 Brussels, Belgium
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ULB Center of Human Genetics, Department of Genetics, Hôpital Universitaire des Enfants Reine Fabiola, Université Libre de Bruxelles, Avenue Jean Joseph Crocq 15, 1020 Brussels, Belgium
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ULB Center of Human Genetics, Department of Genetics, Hôpital Erasme, Université Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium
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Interuniversity Institute of Bioinformatics in Brussels, Université Libre de Bruxelles, La Plaine Campus, Triomflaan CP 263, 1050 Brussels, Belgium
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Department of Pediatric Dermatology, Hôpital Universitaire des Enfants Reine Fabiola, Université Libre de Bruxelles, Avenue Jean Joseph Crocq 15, 1020 Brussels, Belgium
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Laboratoire Hospitalier Universitaire de Bruxelles (LHUB-ULB), Department of Clinical Chemistry, Université Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium
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Pediatric Intensive Care Unit, Hôpital Universitaire des Enfants Reine Fabiola, Université Libre de Bruxelles, Avenue Jean Joseph Crocq 15, 1020 Brussels, Belgium
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Author to whom correspondence should be addressed.
Academic Editor: Alberto Verrotti di Pianella
Received: 29 June 2021 / Revised: 21 July 2021 / Accepted: 26 July 2021 / Published: 1 August 2021
We present a case of a transient acquired zinc deficiency in a breast-fed, 4-month-old-male prematurely born infant, with acrodermatitis enteropathica-like symptoms such as crusted, eroded, erythemato-squamous eruption in periorificial and acral patterns. The laboratory investigations showed low zinc levels in the infant’s and the mother’s serum and in the mother’s milk; genetic analysis did not show any mutation in the SLC39A4 gene, involved in acrodermatitis enteropathica. Acquired zinc deficiency is often found in premature infants because of their increased requirement, the low serum and milk zinc levels in breastfeeding women being also an important risk factor, as in this case. A prompt zinc supplementation is essential for the good prognosis of the disease. View Full-Text
Keywords: zinc deficiency; acrodermatitis enteropathica; premature infant; breastfeeding; zinc supplementation zinc deficiency; acrodermatitis enteropathica; premature infant; breastfeeding; zinc supplementation
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MDPI and ACS Style

D’Amico, G.; De Laet, C.; Smits, G.; Salik, D.; Deprez, G.; Vilain, C.; Perlot, P.; Vicinanza, A. Acquired Zinc Deficiency Mimicking Acrodermatitis Enteropathica in a Breast-Fed Premature Infant. Pediatr. Rep. 2021, 13, 444-449. https://0-doi-org.brum.beds.ac.uk/10.3390/pediatric13030051

AMA Style

D’Amico G, De Laet C, Smits G, Salik D, Deprez G, Vilain C, Perlot P, Vicinanza A. Acquired Zinc Deficiency Mimicking Acrodermatitis Enteropathica in a Breast-Fed Premature Infant. Pediatric Reports. 2021; 13(3):444-449. https://0-doi-org.brum.beds.ac.uk/10.3390/pediatric13030051

Chicago/Turabian Style

D’Amico, Giovanna, Corinne De Laet, Guillaume Smits, Deborah Salik, Guillaume Deprez, Catheline Vilain, Pascale Perlot, and Alfredo Vicinanza. 2021. "Acquired Zinc Deficiency Mimicking Acrodermatitis Enteropathica in a Breast-Fed Premature Infant" Pediatric Reports 13, no. 3: 444-449. https://0-doi-org.brum.beds.ac.uk/10.3390/pediatric13030051

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