Changes in Cognitive Function and in the Levels of Glycosylated Haemoglobin (HbA1c) in Older Women with Type 2 Diabetes Mellitus Subjected to a Cardiorespiratory Exercise Programme
Abstract
:1. Introduction
2. Materials and Methods
2.1. Participants
2.2. Procedure
2.3. Statistical Analysis
3. Results
4. Discussion
4.1. Cardiorespiratory Fitness
4.2. Body Mass Index
4.3. Glycosylated Haemoglobin
4.4. Cognitive State
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Experimental Group (n = 55) | Control Group (n = 52) | |||
---|---|---|---|---|
Mean ± SD | 95% (CI) | Mean ± SD | 95% (CI) | |
Age (years) | 72.3 ± 3.7 | (71.3 to 73.3) | 71 ± 3.3 | (70.1 to 72) |
Weight (kg) | 60.8 ± 3.7 | (59.7 to 61.8) | 60.1 ± 3.5 | (59.1 to 61.1) |
Height (m) | 1.54 ± 0.05 | (1.52 to 1.55) | 1.53 ± 0.04 | (1.51 to 1.54) |
Primary school completed | 100% | 100% | ||
High school completed | 92% | 89% |
Mesocycle 1 | Mesocycle 2 | Mesocycle 3 | Mesocycle 4 | Mesocycle 5 | Mesocycle 6 | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Week | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 |
%VO2max | 40 | 45 | 40 | 45 | 50 | 45 | 50 | 45 | 50 | 55 | 50 | 55 | 50 | 55 | 55 | 60 | 50 | 60 | 55 | 60 | 65 | 55 | 60 | 65 |
Speed (m/min) | 56.2 | 67.6 | 56.2 | 67.6 | 79.0 | 67.6 | 79.6 | 67.6 | 79.0 | 90.4 | 79.0 | 90.4 | 79.0 | 90.4 | 90.4 | 102 | 79.9 | 102 | 90.4 | 102 | 112 | 90.4 | 102 | 112 |
Speed (km/h) | 3.3 | 4.0 | 3.3 | 4.0 | 4.7 | 4.0 | 3.3 | 4.0 | 4.7 | 5.4 | 4.7 | 5.4 | 4.7 | 5.4 | 5.4 | 6.1 | 4.7 | 6.1 | 5.4 | 6.1 | 6.3 | 5.4 | 6.1 | 6.3 |
METs | 2.2 | 2.5 | 2.2 | 2.5 | 2.7 | 2.5 | 2.7 | 2.5 | 2.7 | 3.0 | 2.7 | 3.0 | 2.7 | 3.0 | 3.0 | 3.3 | 2.7 | 3.3 | 3.0 | 3.3 | 3.6 | 3.0 | 3.3 | 3.6 |
Kcal/min | 2.8 | 3.2 | 2.8 | 3.2 | 3.6 | 3.2 | 3.6 | 3.2 | 3.6 | 3.9 | 3.6 | 3.9 | 3.6 | 3.9 | 3.9 | 4.3 | 3.6 | 4.3 | 3.9 | 4.3 | 4.6 | 3.9 | 4.3 | 4.6 |
Experimental Group (n = 55) | |||||||
---|---|---|---|---|---|---|---|
Pre | Post | p-Value | Effect Size | Magnitude | |||
Mean ± SD | 95% (CI) | Mean ± SD | 95% (CI) | ||||
HbA1c (a) | 8.10 ± 0.47 | (7.97 to 8.2) | 7.73 ± 0.55 | (7.6 to 7.9) | <0.001 | −0.66 | Medium |
BMI (a) | 25.54 ± 2.17 | (24.9 to 26.1) | 24.13 ± 2.18 | (23.5 to 24.7) | <0.001 | −0.64 | Medium |
VO2max (a) | 19.24 ± 1.64 | (18.8 to 19.7) | 20.35 ± 1.82 | (19.8 to 20.8) | <0.001 | 0.61 | Medium |
MMSE (b) | 23.04 ± 0.69 | (22.8 to 23.2) | 23.96 ± 0.98 | (23.7 to 24.2) | <0.001 | 0.95 | Large |
Time Or. (b) | 3.71 ± 0.63 | (3.54 to 3.88) | 4.38 ± 0.59 | (4.22 to 4.54) | <0.001 | 1.10 | Large |
Spatial Or. (b) | 3.76 ± 0.58 | (3.61 to 3.92) | 4.20 ± 0.59 | (4.04 to 4.36) | 0.001 | 0.75 | Medium |
Registration (b) | 2.02 ± 0.62 | (1.85 to 2.19) | 2.36 ± 0.59 | (2.20 to 2.52) | 0.001 | 0.57 | Medium |
Calculation (b) | 3.44 ± 0.66 | (3.26 to 3.61) | 3.53 ± 0.72 | (3.33 to 3.72) | 0.384 | 0.13 | Trivial |
Recall (b) | 2.35 ± 0.67 | (2.16 to 2.53) | 2.62 ± 0.49 | (2.49 to 2.75) | 0.009 | 0.46 | Medium |
Language (b) | 1.29 ± 0.17 | (1.24 to 1.34) | 1.32 ± 0.13 | (1.28 to 1.35) | 0.168 | 0.18 | Trivial |
Control Group (n = 52) | |||||||
---|---|---|---|---|---|---|---|
Pre | Post | p-Value | Effect Size | Magnitude | |||
Mean ± SD | 95% (CI) | Mean ± SD | 95% (CI) | ||||
HbA1c (a) | 8.14 ± 0.51 | (8 to 8.3) | 8.45 ± 0.56 | (8.3 to 8.6) | <0.001 | 0.56 | Medium |
BMI (a) | 25.71 ± 2.29 | (25.1 to 26.3) | 26.6 ± 2.44 | (25.9 to 27.3) | <0.001 | 0.36 | Small |
VO2max (a) | 19.35 ± 1.53 | (18.9 to 19.8) | 18.6 ± 1.27 | (18.3 to 19) | <0.001 | −0.55 | Medium |
MMSE (b) | 23.33 ± 0.65 | (23.1 to 23.5) | 22.5 ± 0.98 | (22.2 to 22.7) | <0.001 | −0.86 | Large |
Time Or (b) | 3.65 ± 0.68 | (3.46 to 3.84) | 3.31 ± 0.64 | (3.13 to 3.49) | 0.002 | −0.52 | Medium |
Spatial Or (b) | 3.81 ±0.56 | (3.65 to 3.96) | 3.44 ± 0.75 | (3.23 to 3.65) | 0.002 | −0.55 | Medium |
Registrat. (b) | 1.96 ± 0.39 | (1.85 to 2.07) | 1.48 ± 0.73 | (1.28 to 1.68) | <0.001 | −0.82 | Large |
Calculat. (b) | 3.35 ±0.76 | (3.13 to 3.56) | 2.67 ± 0.78 | (2.45 to 2.89) | <0.001 | −0.87 | Large |
Recall (b) | 2.42 ± 0.67 | (2.24 to 2.61) | 2.04 ± 0.74 | (1.83 to 2.24) | <0.001 | −0.55 | Medium |
Language (b) | 1.31 ±0.16 | (1.27 to 1.35) | 1.20 ± 0.18 | (1.15 to 1.25) | <0.001 | −0.67 | Medium |
Change Exp. Group (n = 55) | Change Control Group (n = 52) | p-Value | Effect Size | Magnitude | |||
---|---|---|---|---|---|---|---|
Mean ± SD | 95% (CI) | Mean ± SD | 95% (CI) | ||||
HbA1c (a) | −0.36 ± 0.31 | (−0.45 to 0.28) | 0.31 ± 0.30 | (0.23 to 0.39) | <0.001 | 2.20 | Large |
BMI (a) | −1.41 ± 1.63 | (−1.85 to −0.96) | 0.88 ± 0.64 | (0.70 to 1.06) | <0.001 | 1.82 | Large |
VO2max (a) | 1.11 ± 1.20 | (0.79 to 1.43) | −0.69 ± 1.31 | (−1.06 to −0.33) | <0.001 | −1.44 | Large |
MMSE (b) | 0.93 ± 1.1 | (0.63 to 1.23) | −0.85 ± 1.04 | (−1.13 to −0.56) | <0.001 | −1.66 | Large |
Time Or (b) | 0.67 ± 0.79 | (0.46 to 0.89) | −0.35 ± 0.74 | (−0.55 to −0.14) | <0.001 | −1.33 | Large |
Spatial Or (b) | 0.44 ± 0.83 | (0.21 to 0.66) | −0.37 ± 0.77 | (−0.58 to −0.15) | <0.001 | −1.00 | Large |
Registrat. (b) | 0.35 ± 0.70 | (0.16 to 0.53) | −0.48 ± 0.61 | (−0.65 to −0.31) | <0.001 | −1.26 | Large |
Calculat. (b) | 0.09 ± 0.78 | (−0.12 to 0.30) | −0.67 ± 0.55 | (−0.83 to −0.52) | <0.001 | −1.13 | Large |
Recall (b) | 0.27 ± 0.73 | (0.07 to 0.47) | −0.38 ± 0.66 | (−0.57 to −0.20) | <0.001 | −0.94 | Large |
Language (b) | 0.03 ± 0.15 | (−0.01 to 0.07) | −0.11 ± 0.16 | (−0.15 to −0.06) | <0.001 | −0.88 | Large |
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Molina-Sotomayor, E.; Onetti-Onetti, W.; Castillo-Rodríguez, A.; González-Jurado, J.A. Changes in Cognitive Function and in the Levels of Glycosylated Haemoglobin (HbA1c) in Older Women with Type 2 Diabetes Mellitus Subjected to a Cardiorespiratory Exercise Programme. Sustainability 2020, 12, 5038. https://0-doi-org.brum.beds.ac.uk/10.3390/su12125038
Molina-Sotomayor E, Onetti-Onetti W, Castillo-Rodríguez A, González-Jurado JA. Changes in Cognitive Function and in the Levels of Glycosylated Haemoglobin (HbA1c) in Older Women with Type 2 Diabetes Mellitus Subjected to a Cardiorespiratory Exercise Programme. Sustainability. 2020; 12(12):5038. https://0-doi-org.brum.beds.ac.uk/10.3390/su12125038
Chicago/Turabian StyleMolina-Sotomayor, Edgardo, Wanesa Onetti-Onetti, Alfonso Castillo-Rodríguez, and Jose Antonio González-Jurado. 2020. "Changes in Cognitive Function and in the Levels of Glycosylated Haemoglobin (HbA1c) in Older Women with Type 2 Diabetes Mellitus Subjected to a Cardiorespiratory Exercise Programme" Sustainability 12, no. 12: 5038. https://0-doi-org.brum.beds.ac.uk/10.3390/su12125038