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Article

Evaluation of Resistance to Fescue Toxicosis in Purebred Angus Cattle Utilizing Animal Performance and Cytokine Response

1
Department of Animal Science, North Carolina State University, Raleigh, NC 27695, USA
2
Director of Agriculture, The Biltmore Company, Asheville, NC 28803, USA
3
Department of Animal Science, Texas A&M University, College Station, TX 77843, USA
4
Department of Animal Science, Iowa State University, Ames, IA 50011, USA
*
Author to whom correspondence should be addressed.
Received: 15 October 2020 / Revised: 8 December 2020 / Accepted: 10 December 2020 / Published: 14 December 2020
(This article belongs to the Special Issue Global Impact of Ergot Alkaloids)
Fescue toxicosis is a multifaceted syndrome common in cattle grazing endophyte-infected tall fescue; however, varying symptomatic responses potentially imply genetic tolerance to the syndrome. It was hypothesized that a subpopulation of animals within a herd would develop tolerance to ergot alkaloid toxicity. Therefore, the goals of this study were to develop selection criteria to identify tolerant and susceptible animals within a herd based on animal performance, and then examine responsive phenotypic and cytokine profiles to fescue toxicosis. Angus cows grazed endophyte-infected tall fescue at two locations for 13 weeks starting in mid-April 2016. Forage measurements were collected to evaluate ergot alkaloid exposure during the study. A post hoc analysis of animal performance was utilized to designate cattle into either tolerant or susceptible groups, and weekly physiological measurements and blood samples were collected to evaluate responses to chronic exposure to endophyte-infected tall fescue. Findings from this study support the proposed fescue toxicosis selection method formulated herein, could accurately distinguish between tolerant and susceptible animals based on the performance parameters in cattle chronically exposed to ergot alkaloids, and provides evidence to warrant additional analysis to examine the impact of ergot alkaloids on immune responsiveness in cattle experiencing fescue toxicosis. View Full-Text
Keywords: fescue toxicosis; genetic tolerance; cytokines; cow productivity fescue toxicosis; genetic tolerance; cytokines; cow productivity
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MDPI and ACS Style

Poole, D.H.; Mayberry, K.J.; Newsome, M.; Poole, R.K.; Galliou, J.M.; Khanal, P.; Poore, M.H.; Serão, N.V.L. Evaluation of Resistance to Fescue Toxicosis in Purebred Angus Cattle Utilizing Animal Performance and Cytokine Response. Toxins 2020, 12, 796. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins12120796

AMA Style

Poole DH, Mayberry KJ, Newsome M, Poole RK, Galliou JM, Khanal P, Poore MH, Serão NVL. Evaluation of Resistance to Fescue Toxicosis in Purebred Angus Cattle Utilizing Animal Performance and Cytokine Response. Toxins. 2020; 12(12):796. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins12120796

Chicago/Turabian Style

Poole, Daniel H., Kyle J. Mayberry, McKayla Newsome, Rebecca K. Poole, Justine M. Galliou, Piush Khanal, Matthew H. Poore, and Nick V.L. Serão 2020. "Evaluation of Resistance to Fescue Toxicosis in Purebred Angus Cattle Utilizing Animal Performance and Cytokine Response" Toxins 12, no. 12: 796. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins12120796

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