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Brief Report

Novel Binding Mechanisms of Fusion Broad Range Anti-Infective Protein Ricin A Chain Mutant-Pokeweed Antiviral Protein 1 (RTAM-PAP1) against SARS-CoV-2 Key Proteins in Silico

by 1,*, 2 and 3
1
Ophiuchus Medicine Inc., Vancouver, BC V6B 0M3, Canada
2
Biotechnology, Johns Hopkins University, AAP, Baltimore, MD 21218, USA
3
AscentGene Inc., Gaithersburg, MD 20878, USA
*
Author to whom correspondence should be addressed.
Received: 28 August 2020 / Revised: 10 September 2020 / Accepted: 14 September 2020 / Published: 17 September 2020
(This article belongs to the Special Issue Toxin and Immunotoxin Based Therapeutic Approaches)
The deadly pandemic named COVID-19, caused by a new coronavirus (SARS-CoV-2), emerged in 2019 and is still spreading globally at a dangerous pace. As of today, there are no proven vaccines, therapies, or even strategies to fight off this virus. Here, we describe the in silico docking results of a novel broad range anti-infective fusion protein RTAM-PAP1 against the various key proteins of SARS-CoV-2 using the latest protein-ligand docking software. RTAM-PAP1 was compared against the SARS-CoV-2 B38 antibody, ricin A chain, a pokeweed antiviral protein from leaves, and the lectin griffithsin using the special CoDockPP COVID-19 version. These experiments revealed novel binding mechanisms of RTAM-PAP1 with a high affinity to numerous SARS-CoV-2 key proteins. RTAM-PAP1 was further characterized in a preliminary toxicity study in mice and was found to be a potential therapeutic candidate. These findings might lead to the discovery of novel SARS-CoV-2 targets and therapeutic protein structures with outstanding functions. View Full-Text
Keywords: fusion proteins; ricin; pokeweed antiviral protein; COVID-19; SARS-CoV-2; antiviral agent; ribosome-inactivating proteins fusion proteins; ricin; pokeweed antiviral protein; COVID-19; SARS-CoV-2; antiviral agent; ribosome-inactivating proteins
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MDPI and ACS Style

Hassan, Y.; Ogg, S.; Ge, H. Novel Binding Mechanisms of Fusion Broad Range Anti-Infective Protein Ricin A Chain Mutant-Pokeweed Antiviral Protein 1 (RTAM-PAP1) against SARS-CoV-2 Key Proteins in Silico. Toxins 2020, 12, 602. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins12090602

AMA Style

Hassan Y, Ogg S, Ge H. Novel Binding Mechanisms of Fusion Broad Range Anti-Infective Protein Ricin A Chain Mutant-Pokeweed Antiviral Protein 1 (RTAM-PAP1) against SARS-CoV-2 Key Proteins in Silico. Toxins. 2020; 12(9):602. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins12090602

Chicago/Turabian Style

Hassan, Yasser; Ogg, Sherry; Ge, Hui. 2020. "Novel Binding Mechanisms of Fusion Broad Range Anti-Infective Protein Ricin A Chain Mutant-Pokeweed Antiviral Protein 1 (RTAM-PAP1) against SARS-CoV-2 Key Proteins in Silico" Toxins 12, no. 9: 602. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins12090602

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