Histone Demethylase JMJD2D: A Novel Player in Colorectal and Hepatocellular Cancers
Abstract
:Simple Summary
Abstract
1. Introduction
2. JMJD2D Promotes Gene Transcription by Antagonizing H3K9 Methylation
3. JMJD2D Has Multiple Biological Functions
3.1. JMJD2D Facilitates the Functions of Androgen Receptor
3.2. JMJD2D Plays a Key Role in DNA Damage Repair, DNA Replication, and Cell Cycle Regulation
3.3. JMJD2D Modulates the Inflammatory Response
4. JMJD2D Is a Pivotal Activator of Colorectal and Hepatocellular Cancers
4.1. JMJD2D Promotes the Progression of Colorectal Cancer
4.2. The Pivotal Role of JMJD2D in the Pathogenesis of Hepatocellular Cancer
4.3. JMJD2D and Other Tumors
5. Targeted Cancer Therapy against JMJD2D
6. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Chen, Q.; Peng, K.; Mo, P.; Yu, C. Histone Demethylase JMJD2D: A Novel Player in Colorectal and Hepatocellular Cancers. Cancers 2022, 14, 2841. https://0-doi-org.brum.beds.ac.uk/10.3390/cancers14122841
Chen Q, Peng K, Mo P, Yu C. Histone Demethylase JMJD2D: A Novel Player in Colorectal and Hepatocellular Cancers. Cancers. 2022; 14(12):2841. https://0-doi-org.brum.beds.ac.uk/10.3390/cancers14122841
Chicago/Turabian StyleChen, Qiang, Kesong Peng, Pingli Mo, and Chundong Yu. 2022. "Histone Demethylase JMJD2D: A Novel Player in Colorectal and Hepatocellular Cancers" Cancers 14, no. 12: 2841. https://0-doi-org.brum.beds.ac.uk/10.3390/cancers14122841