Completion Pneumonectomy for Non-Small-Cell Lung Cancer: Does Induction Treatment Influence Postoperative Outcomes?
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Clinical Considerations
2.2. Surgical Procedure
2.3. Statistical Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
- Subotich, D.; Van Schil, P.; Grigoriu, B. Optimizing treatment for postoperative lung cancer recurrence. Eur. Resp. J. 2016, 47, 374–378. [Google Scholar] [CrossRef] [PubMed]
- Tronc, F.; Grégoire, J.; Rouleau, J.; Deslauriers, J. Techniques of pneumonectomy. Completion pneumonectomy. Chest Surg. Clin. N. Am. 1999, 9, 393–405. [Google Scholar] [PubMed]
- Cardillo, G.; Galetta, D.; van Schil, P.; Zuin, A.; Filosso, P.; Cerfolio, R.J.; Forcione, A.R.; Carleo, F. Completion pneumonectomy: A multicenter international study on 165 patients. Eur. J. Cardiothorac. Surg. 2012, 42, 405–409. [Google Scholar] [CrossRef]
- Subotic, D.; Molins, L.; Soldatovic, I.; Moskovljevic, D.; Collado, L.; Hernandez, J. Completion pneumonectomy: A valuable option for lung cancer recurrence or new primaries. World J. Surg. Oncol. 2018, 16, 98. [Google Scholar] [CrossRef]
- Miller, D.L.; Deschamps, C.; Jenkins, G.D.; Bernard, A.; Allen, M.S.; Pairolero., P.C. Completion pneumonectomy: Factors affecting operative mortality and cardiopulmonary morbidity. Ann. Thorac. Surg. 2002, 74, 876–884. [Google Scholar] [CrossRef]
- Sezen, C.B.; Kocaturk, C.I.; Bilen, S.; Kalafat, C.E.; Aker, C.; Karapinar, K. Long-term outcoes of completion pneumonectomy for non-small cell lung cancer. Acta Chir. Bel. 2019, 119, 303–308. [Google Scholar]
- Chataigner, O.; Fadel, E.; Yildizeli, B.; Achir, A.; Mussot, S.; Fabre, D.; Mercier, O.; Dartevelle, P.G. Factors affecting early and long-term outcomes after completion pneumonectomy. Eur. J. Cardiothorac. Surg. 2008, 33, 837–843. [Google Scholar] [CrossRef] [Green Version]
- Terzi, A.; Lonardoni, A.; Falezza, G.; Scanagatta, P.; Santo, A.; Furlan, G.; Calabrò, F. Completion pneumonectomy for non-small cell lung cancer: Experience with 59 cases. Eur. J. Cardiothorac. Surg. 2002, 22, 30–34. [Google Scholar] [CrossRef] [Green Version]
- Von Elm, E.; Altman, D.G.; Egger, M.; Pocock, S.J.; Gøtzsche, P.C.; Vandenbroucke, J.P. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: Guidelines for reporting observational studies. Lancet 2007, 370, 1453–1457. [Google Scholar] [CrossRef]
- Martini, N.; Melamed, M.R. Multiple primary lung cancers. J. Thorac. Cardiovasc. Surg. 1975, 70, 606–612. [Google Scholar] [CrossRef]
- Goldstraw, P.; Chansky, K.; Crowley, J.; Rami-Porta, R.; Asamura, H.; Eberhardt, W.E.; Nicholson, A.G.; Groome, P.; Mitchell, A.; Bolejack, V. International Association for the Study of Lung Cancer Staging and Prognostic Factors Committee, Advisory Boards, and Participating Institutions. International Association for the Study of Lung Cancer Staging and Prognostic Factors Committee Advisory Boards and Participating Institutions. The IASLC Lung Cancer Staging Project: Proposals for Revision of the TNM Stage Groupings in the Forthcoming (Eighth) Edition of the TNM Classification for Lung Cancer. J. Thorac. Oncol. 2016, 11, 39–51. [Google Scholar] [PubMed] [Green Version]
- McGovern, E.M.; Trastek, V.F.; Pairolero, P.C.; Payne, W.S. Completion pneumonectomy: Indications, complications, and results. Ann. Thorac. Surg. 1988, 46, 141–146. [Google Scholar] [CrossRef]
- Guggino, G.; Doddoli, C.; Barlesi, F.; Acri, P.; Chetaille, B.; Thomas, P.; Giudicelli, R.; Fuentes, P. Completion pneumonectomy in cancer patients: Experience with 55 cases. Eur. J. Cardiothorac. Surg. 2004, 25, 449–455. [Google Scholar] [CrossRef] [Green Version]
- Regnard, J.F.; Icard, P.; Magdeleinat, P.; Jauffret, B.; Farés, E.; Levaseur, P. Completion pneumonectomy: Experience in eighty patients. J. Thorac. Cardiovasc. Surg. 1999, 117, 1095–1101. [Google Scholar] [CrossRef] [Green Version]
- Zhang, P.; Jiang, C.; He, W.; Song, N.; Zhou, X.; Jiang, G. Completion pneumonectomy for lung cancer treatment: Early and long term outcomes. J. Cardiothorac. Surg. 2012, 7, 107. [Google Scholar] [PubMed] [Green Version]
- White, A.; Kukukak, S.; Lee, D.N.; Bueno, R.; Jaklitsch, M.; Mentzer, S.; Sugarbaker, D.; Wee, J.; Swanson, S.J. Completion pneumonectomy is safe and effective in selected patients with recurrent non-small cell lung cancer. J. Thorac. Dis. 2020, 12, 217–222. [Google Scholar] [CrossRef] [PubMed]
- Grégoire, J.; Deslauriers, J.; Guojin, L.; Rouleau, J. Indications, risks, and results of completion pneumonectomy. J. Torac. Cardiovasc. Surg. 1993, 105, 918–924. [Google Scholar] [CrossRef]
- Fujiomoto, T.; Zaboura, G.; Fechner, S.; Hillejan, L.; Schroder, T.; Marra, A.; Krbek, T.; Hinterthaner, M.; Greschuchna, D.; Stamatis, G. Completion pneumonectomy: Current indications, complications, and results. J. Thorac. Cardiovasc. Surg. 2001, 121, 484–490. [Google Scholar] [CrossRef] [Green Version]
- Tabutin, M.; Couraud, S.; Guibert, B.; Mulsant, P.; Souquet, P.J.; Tronc, F. Completion pneumonectomy in patients with cancer: Postoperative survival and mortality factors. J. Thorac. Oncol. 2012, 7, 1556–1562. [Google Scholar] [CrossRef] [Green Version]
- Haraguchi, S.; Koizumi, K.; Hirata, T.; Hirai, K.; Mikami, I.; Kubokura, H.; Shimizu, K. Surgical results of completion pneumonectomy. Ann. Thorac. Surg. 2011, 17, 24–28. [Google Scholar] [CrossRef] [Green Version]
- Spiro, S.G.; Douse, J.; Read, C.; Janes, S. Complications of lung cancer treatment. Semin. Respir. Crit. Care Med. 2008, 29, 302–317. [Google Scholar] [CrossRef] [PubMed]
- Bernard, A.; Deschamps, C.; Allen, M.S.; Miller, D.L.; Trastek, V.F.; Jenkins, G.D.; Pairolero, P.C. Pneumonectomy for malignant disease: Factors affecting early morbidity and mortality. J. Thorac. Cardiovasc. Surg. 2001, 121, 1076–1082. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Leo, F.; Solli, P.; Veronesi, G.; Radice, D.; Floridi, A.; Gasparri, R.; Petrella, F.; Borri, A.; Galetta, D.; Spaggiari, L. Does chemotherapy increase the risk of respiratory complications after pneumonectomy? J. Thorac. Cardiovasc. Surg. 2006, 132, 519–523. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Van Schil, P.; Van Meerbeeck, J.; Kramer, G.; Splinter, T.; Legrand, C.; Giaccone, G.; Manegold, C.; van Zandwijk, N. Morbidity and mortality in the surgery arm of EORTC 08941 trial. Eur. Respir. J. 2005, 26, 192–197. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Gilligan, D.; Nicolson, M.; Smith, I.; Groen, H.; Dalesio, O.; Goldstraw, P.; Hatton, M.; Hopwood, P.; Manegold, C.; Schramel, F.; et al. Preoperative chemotherapy in patients with resectable non-small cell lung cancer: Results of the MRC LU22/NVALT 2/EORTC 08012 multicentre randomised trial and update of systematic review. Lancet 2007, 369, 1929–1937. [Google Scholar] [CrossRef]
- Massard, G.; Wihlm, J.M.; Ameur, S.; Jung, G.M.; Rougé, C.; Dumont, P.; Roeslin, N.; Morand, G. Association of bronchial and pharyngo-laryngeal malignancies. A reappraisal. Eur. J. Cardiothorac. Surg. 1996, 10, 397–402. [Google Scholar]
- Périé, S.; Laccourreye, O.; Bou-Malhab, F.; Brasnu, D. Aspiration in unilateral recurrent laryngeal nerve paralysis after surgery. Am. J. Otolaryngol. 1998, 19, 18–23. [Google Scholar] [CrossRef]
- Cocuzza, S.; Di Luca, M.; Maniaci, A.; Russo, M.; Di Mauro, P.; Migliore, M.; Serra, A.; Spinato, G. Precision treatment of post pneumonectomy unilateral laryngeal paralysis due to cancer. Future Oncol. 2020, 16, 45–53. [Google Scholar] [CrossRef]
- Mom, T.; Filaire, M.; Advenier, D.; Guichard, C.; Naamee, A.; Escande, G.; Llompart, X.; Vallet, L.; Gabrillargues, J.; Courtalhiac, C.; et al. Concomitant type I thyroplasty and thoracic operations for lung cancer: Preventing respiratory complications associated with vagus or recurrent laryngeal nerve injury. J. Thorac. Cardiovasc. Surg. 2001, 121, 642–648. [Google Scholar]
- Fournel, P.; Robinet, G.; Thomas, P.; Souquet, P.J.; Léna, H.; Vergnenégre, A.; Delhoume, J.Y.; Le Treut, J.; Silvani, J.A.; Dansin, E.; et al. Randomized phase III trial of sequential chemoradiotherapy compared with concurrent chemoradiotherapy in locally advanced non-small-cell lung cancer: Groupe Lyon-Saint-Etienne d’Oncologie Thoracique-Groupe Français de Pneumo-Cancérologie NPC 95-01 Study. J. Clin. Oncol. 2005, 23, 5910–5917. [Google Scholar]
- Albain, K.S.; Rusch, V.W.; Crowley, J.J.; Rice, T.W.; Turrisi, A.T., 3rd; Weick, J.K.; Lonchyna, V.A.; Presant, C.A.; McKenna, R.J.; Gandara, D.R. Concurrent cisplatin/etoposide plus chest radiotherapy followed by surgery for stages IIIA (N2) and IIIB non-small-cell lung cancer: Mature results of Southwest Oncology Group phase II study 8805. J. Clin. Oncol. 1995, 13, 1880–1892. [Google Scholar] [CrossRef] [PubMed]
- Bueno, R.; Richards, W.G.; Swanson, S.J.; Jaklitsch, M.T.; Lukanich, J.M.; Mentzer, S.J.; Sugarbaker, D.J. Nodal stage after induction therapy for stage IIIA lung cancer determines patient survival. Ann. Thorac. Surg. 2000, 70, 1826–1831. [Google Scholar] [CrossRef]
- Allen, A.M.; Mentzer, S.J.; Yeap, B.Y.; Soto, R.; Baldini, E.; Rabin, M.S.; Sugarbaker, D.J.; Bueno, R. Pneumonectomy after chemoradiation: The Dana-Farber Cancer Institute/Brigham and Women’s Hospital experience. Cancer 2008, 112, 1106–1113. [Google Scholar] [CrossRef] [PubMed]
- Caglar, H.B.; Baldini, E.H.; Othus, M.; Rabin, M.S.; Bueno, R.; Sugarbaker, D.J.; Mentzer, S.J.; Jänne, P.A.; Johnson, B.E.; Allen, A.M. Outcomes of patients with stage III nonsmall cell lung cancer treated with chemotherapy and radiation with and without surgery. Cancer 2009, 115, 4156–4166. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Pan, X.; Fu, S.; Shi, J.; Yang, J.; Zhao, H. The early and long-term outcomes of completion pneumonectomy: Report of 56 cases. Interact Cardiovasc. Thorac. Surg. 2014, 19, 436–440. [Google Scholar] [CrossRef]
- Austin, P.C. An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies. Multivar. Behav. Res. 2011, 46, 399–424. [Google Scholar] [CrossRef] [PubMed] [Green Version]
Variable | IT (n = 23) | No-IT (n = 46) | p Value |
---|---|---|---|
Age (y ± SD) | 62.70 ± 6.22 | 61.62 ± 5.86 | 0.75 |
Sex (male/female) | 17M/6F | 33M/13F | 0.45 |
Side (right/left) | 15/8 | 32/14 | 0.52 |
FEV1 (mean % predicted ± SD) FVC (mean % predicted ± SD) | 81.72 ± 12.16 79.73 ± 16.88 | 80.48 ± 13.85 80.62 ± 14.67 | 0.65 0.73 |
DLCO (mean % ± SD) | 76.30 ± 15.23 | 78.45 ± 16.08 | 0.69 |
Histology (%) | |||
Squamous | 8 (34.8) | 15 (32.6) | |
Adenocarcinoma | 13 (56.5) | 25 (54.3) | |
Others | 2 (8.7) | 6 (13.1) | 0.34 |
Pathological stage (%) | |||
I | 7 (30.4) | 12 (26.1) | |
II | 11 (47.8) | 25 (54.3) | |
III | 5 (21.7) | 9 (19.5) | 0.38 |
Extended resections | |||
Chest wall | 3 (13.0) | 7 (15.2) | |
Pulmonary artery | 3 (13.0) | 5 (10.8) | |
Left atrium | 2 (8.7) | 1 (2.2) | |
Diaphragm | 1 (4.3) | 2 (4.3) | |
Aorta Tracheal sleeve pneumonectomy | 1 (4.3) 2 (8.7) | 0 3 (6.5) | 0.12 0.23 |
Variable | IT (n = 23) | No-IT (n = 46) | p Value |
---|---|---|---|
Intraoperative mortality (%) 30-day mortality (%) | 0 2 (8.7) | 0 3 (6.5) | 0.12 |
Morbidity (%) | 9 (39.1) | 17 (36.9) | 0.54 |
Major | 2 (8.7) | 3 (6.5) | 0.12 |
Diaphragmatic hernia | 1 (4.3) | 0 | |
Cardiac hernia | 0 | 1 (2.2) | |
Bronchopleural fistula TIA | 1 (4.3) 0 | 1 (2.2) 1 (2.2) | |
Minor | 7 (30.4) | 14 (30.4) | 0.43 |
Pulmonary | 4 (17.4) | 8 (17.4) | |
Cardiac | 2 (8.7) | 5 (10.8) | |
Neurological ICU stay (days, median) Hospital stay (days, median) | 1 (4.3) 1 8 | 1 (2.2) 1 7 | 1.00 0.83 |
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Galetta, D.; Spaggiari, L. Completion Pneumonectomy for Non-Small-Cell Lung Cancer: Does Induction Treatment Influence Postoperative Outcomes? Cancers 2022, 14, 3408. https://0-doi-org.brum.beds.ac.uk/10.3390/cancers14143408
Galetta D, Spaggiari L. Completion Pneumonectomy for Non-Small-Cell Lung Cancer: Does Induction Treatment Influence Postoperative Outcomes? Cancers. 2022; 14(14):3408. https://0-doi-org.brum.beds.ac.uk/10.3390/cancers14143408
Chicago/Turabian StyleGaletta, Domenico, and Lorenzo Spaggiari. 2022. "Completion Pneumonectomy for Non-Small-Cell Lung Cancer: Does Induction Treatment Influence Postoperative Outcomes?" Cancers 14, no. 14: 3408. https://0-doi-org.brum.beds.ac.uk/10.3390/cancers14143408