Astrocytes in Neurodegenerative Diseases: A Perspective from Tauopathy and α-Synucleinopathy
Abstract
:1. Introduction
2. Astrocytes in Tauopathies
2.1. Tau and Tauopathies
2.2. Astrocytes as a Modulator of AD and Tauopathies
2.3. Astrocyte in the Propagation of Tauopathies
2.4. Tauopathies Are Associated with Widespread Reactive Astrogliosis
3. Astrocytes and α-Synucleinopathies
3.1. α-Synuclein and Parkinson’s Disease
3.2. Intercellular Transmission of α-Syn in α-Synucleinopathies
3.3. Role of Astrocyte in α-Syn-Associated Neuroinflammation
4. Conclusions and Perspectives
Author Contributions
Funding
Institutional Review Board Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Gene | Glia Cell Type | Pathway | Effect on Aβ | Effect on Tau |
---|---|---|---|---|
APOE [30] | Astrocyte | Lipid metabolism, immune response | Aβ clearance [34] | Tau aggregation and toxicity [38,39] |
CLU(APOJ) [40,41] | Astrocyte | Lipid metabolism, immune response | Amyloid formation [42] | Unknown |
FERMT2 [43] | Astrocyte | Integrin signaling, and cell adhesion, angiogenesis | Aβ production [44] | Tau proteostasis [45] |
WWOX [29] | Astrocyte | Putative oxidoreductase, neuronal differentiation [46] | Aβ aggregation [47] | Tau phosphorylation, NFT formation [47,48] |
IL1RAP [49] | Astrocyte, oligodendrocyte | Neuronal synaptogenesis [50] | Unknown | Unknown |
PTK2B [51] | Microglia, astrocyte | Immune response, endocytosis, synaptic transmission | Unknown | Tau toxicity [52] |
SORL1 [53] | Microglia, astrocyte | Endosomal traffic | APP trafficking [54] | Unknown |
CELF1 [55] | Astrocyte, oligodendrocyte, microglia | Unknown | Unknown | Unknown |
EPHA1 [56,57] | Astrocyte, oligodendrocyte, microglia | Cell migration and proliferation, immune response | Unknown | Tau toxicity [52] |
CD2AP [56,57] | Astrocyte, oligodendrocyte, microglia | Neurite structure modulation and blood-brain barrier integrity | Aβ production [58,59] | Tau toxicity [60] |
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Wang, P.; Ye, Y. Astrocytes in Neurodegenerative Diseases: A Perspective from Tauopathy and α-Synucleinopathy. Life 2021, 11, 938. https://0-doi-org.brum.beds.ac.uk/10.3390/life11090938
Wang P, Ye Y. Astrocytes in Neurodegenerative Diseases: A Perspective from Tauopathy and α-Synucleinopathy. Life. 2021; 11(9):938. https://0-doi-org.brum.beds.ac.uk/10.3390/life11090938
Chicago/Turabian StyleWang, Peng, and Yihong Ye. 2021. "Astrocytes in Neurodegenerative Diseases: A Perspective from Tauopathy and α-Synucleinopathy" Life 11, no. 9: 938. https://0-doi-org.brum.beds.ac.uk/10.3390/life11090938